50 resultaten
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
ARA290 regenerates growth of nerve fibers and gives improvement of illness.
A tracer coctail combining indocyanine green and radioactive colloids will allow enhanced detection of the sentinel lymph node in breast cancer patients.
The protein status of an individual effects food preferences and intake. If the protein status is low, products high in protein will elicit greater reward.
The purpose of this study is: 1. To identify clinical and biological predictors for the development of IRIS in HIV infected patients and; 2. To obtain insight into the pathogenesis of this syndrome; 3. To describe the epidemiological pattern of IRIS…
We hypothesize that the vascularity of the fibroid is associated with: 1. Growth potential of the fibroid; 2. The fibroid size reduction after GnRHa treatment.
The primary objective of the CCR study is to monitor clinically relevant parameters of ACS patients undergoing PCI with a follow-up of 1 year, after updating treatment guidelines of the participating network to include prasugrel as the first line…
Amendment (5-apr-2013): Dosing-time of sunitinib may alter the pharmacokinetics
TEE has proven to be an invaluable tool in evaluation and guiding treatment in both adult and paediatric patients in the operating room and in the ICU. In the ICU the development of smaller TEE probes has led to the trans-nasal introduction of these…
Fluorescent near-infrared imaging can be used to identify the ureters using a low dose methylene blue.
It is hypothesized that participants who received information about social modeling effects in the intervention group consume less (snack) food compared to participants in the control group.
We hypothesize that RPCA is as effective in reducing pain relief scores as EA, with lower costs and easier achievement of 24 hours availability of pain relief for low risk women in labor.
The aim of this study is to test, by means of a randomized controlled trial, the hypothesis that application of PAS therapy with low-frequency acoustic vibrations to demented patients in nursing homes will lead to a significant decrease of nocturnal…
The objective of this thesis is to get insight into the effects of internal audits on patient safety and on health care professional’s behavior in an academic hospital at ward level.
1. That adherence to the WHO recommendations (2003) for early child feeding among low-income Quetzaltenango mothers, specifically exclusive breastfeeding up to 6 months, is associated with higher growth attainment and greater disease resistance; 2.…
Intra-operative evaluation of efficacy and safety of a new lead for steering Deep Brain Stimulation.
Primary Hypothesis: 1. Sapiens lead is able to provide stimulation to the brain safely and elicit equivalent effects as commercial DBS systems. Secondary Hypotheses: 1. Steering can modulate the thresholds of stimulation-induced effects; 2. The…
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
It is expected that using the DEM-DISC will decrease the number of unmet needs and increase the number of met needs in people with dementia and their informal caregivers. Informal caregivers using DEM-DISC are expected to feel less burdened and will…
For patients with a diffuse large B cell lymphoma (DLBCL) the efficacy of the anti-CD20 monoclonal antibody rituximab combined with salvage chemotherapy in the second-line setting has decreased due to more effective first-line treatment with…
It is hypothesized that the mindfulness based intervention will be associated with a reduction in psychological symptoms and increase in quality of life. In addition, it is hypothesized that patients scoring high on psychological mindedness at…