Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
Bron
Verkorte titel
Aandoening
hypoxia, pulmonary hypertension, COPD, diabetes,
Ondersteuning
Onderzoeksproduct en/of interventie
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Uitkomstmaten
Primaire uitkomstmaten
1. Ventilatory response: We will monitor ventilation continuously and afterwards analyze these data based on acute response as well as non linear modeling;<br>
2. Pulmonary arterial pressure will be estimated using the tricuspid valve maximum gradient, which is a good estimate of the systolic pulmonary arterial pressure, using echocardiography. We will monitor the PAP every minute for the first 20 minutes and thereafter every 5 minutes.
Achtergrond van het onderzoek
The HVR and HPV are effected by several metabolic processes. In this study we want to investigate whether these reflexes are under direct influence of glucose levels and what the magnitude of the effect is.
Doel van het onderzoek
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
Onderzoeksopzet
Every minute for the first 20 minutes, hereafter every 5 minutes for the remaining 40 minutes.
Onderzoeksproduct en/of interventie
Crossover trial, with randomly a hyperglycaemic (15 mmol/l) hypoxic episode of 60 minutes and a normoglycaemic hypoxic episode of 60 minutes. Hyperglycaemia accomplished according the glucose clamp technique of Defronzo et al. Two episodes at least to weeks apart.
Publiek
LUMC, P5-Q
Rob Lindeman
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
c.r.lindeman@lumc.nl
Wetenschappelijk
LUMC, P5-Q
Rob Lindeman
Leiden 2300 RC
The Netherlands
+31 (0)71 5262301
c.r.lindeman@lumc.nl
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
Healthy volunteers aged 18-45 with echo evidence of tricuspid regurgitation during systole, which is not clinically relevant but in fact can be demonstrated in most normal individuals.
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
1. Obesity (BMI > 30);
2. Presence of medical disease: heart-, lung-, liver-, kidney- and lung disease; diabetes;
3. Presence of psychiatric disease;
4. History of chronic alcohol or drug use;
5. Possibility of pregnancy;
6. Lactation.
Opzet
Deelname
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL3088 |
NTR-old | NTR3236 |
Ander register | METC LUMC / CCMO : P11.058 / NL35083.058.11; |
ISRCTN | ISRCTN wordt niet meer aangevraagd. |