129 resultaten
There will be a relation between the level lidocaine in newborn, the level in mother and drug-delivery interval.
The primary objective of this study is to evaluate the web-based intervention 'Leven met Pijn' in comparison to a minimal intervention condition and a waiting list control condition in terms of a decrease in pain interference in daily life…
We hypothesize that motivational and behavioral characteristics of eating behavior, in addition to genetic and environmental factors play a major role in the development of obesity. We aim to identify obesity subtypes based on these factors.
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
Reversibility of oral direct factor Xa inhibitors rivaroxaban and apixaban will be the same when a lower dosage of prothrombin complex concentrate (Cofact®) is used. Infusion with doses of 37.5 or 25 units/kg of PCC would be able to reverse the…
1. Cancer survivors experience more meaning in life after the intervention; 2. Psychological wellbeing in cancer survivors improves after the intervention.
High-dose, weekly erlotinib is a therapeutic option for EGFR-mutated NSCLC patients with leptomeningeal metastases while on EGFR-TKI therapy. In one of the patients treated with this dose schedule not only the leptomeningeal metastases showed…
Yellow fever specific T cells are present in 70% of patients using immunosuppressive medication versus 99% of healthy volunteers.
8 weeks after the PRF treatment we expect that the electric quantitative sensory testing (eQST) values are higher compared to the eQST values before the PRF treatment. This means that patients can tolerate a higher stimulation threshold. The…
It is expected that using the DEM-DISC will decrease the number of unmet needs and increase the number of met needs in people with dementia and their informal caregivers. Informal caregivers using DEM-DISC are expected to feel less burdened and will…
For patients with a diffuse large B cell lymphoma (DLBCL) the efficacy of the anti-CD20 monoclonal antibody rituximab combined with salvage chemotherapy in the second-line setting has decreased due to more effective first-line treatment with…
In adult congenital heart disease patients with exercise-induced pulmonary arterial hypertension, treatment with bosentan lowers the mean pulmonary arterial pressure, which may result in improvement of the cardiopulmonary circulation,…
It is hypothesized that the mindfulness based intervention will be associated with a reduction in psychological symptoms and increase in quality of life. In addition, it is hypothesized that patients scoring high on psychological mindedness at…
This study hypothesizes that an oxytocin inhalation will increase prosocial behavior and reduces social anxiety during social interaction specifically in patients with SAD in comparison to a clinical and healthy control group.
We hypothesized that avoidance of drainage after pancreaticoduodenectomy leads to less secondary interventions, less complications and a reduction in length of hospital stay.
The objective of this thesis is to get insight into the effects of internal audits on patient safety and on health care professional’s behavior in an academic hospital at ward level.
Adding prebiotics or ferments to infant formula may improve digestive comfort in infants. Therefore, the infant formula tested in this study, combining these ingredients, may contribute to improved digestive comfort. In this study it also has been…
Secondary cytoreductive surgery added to chemotherapy will increase progression free survival in selected patients with first platinum sensitive recurrence of ovarian cancer with a minimal negative effect on their health-related quality of life.
Hyperglycaemia alters the sustained hypoxic pulmonary vasoconstriction (HPV) and the hypoxic ventilatory response (HVR).
Recurrent miscarriages is defined as three or more consecutive miscarriages prior to the 20th week of gestation. Whenever the diagnosis ‘recurrent miscarriages’ is established, an underlying cause may be identified in about 25-50% of cases. A…