631 resultaten
The primary objective is to determine whether JWH-018 can be safely administered in healthy volunteers in doses up to 3 mg. Therefore participants will be continuously monitored by a medical doctor and vital signs, laboratory clinical safety and…
The main objective of the study is to investigate if positional therapy during sleeping, using the LEFT device, reduces nighttime gastroesophageal reflux symptoms.
The hypothesis is that random assignment to C1-INH in patients with moderate and severe TBI will experience a reduction in ICP directed therapy intensity levels (TIL) compared to random assignment to placebo (difference of 2.2). Secondary, if…
First, it will be investigated which is the best diagnostic tool for imbalance in CP. Second, it will be determined whether balance training can promote balance control in CP, and whether the improvements will be maintained after a follow-up period…
To evaluate the effect of an enhanced perioperative care program added on to usual care. It is hypothesized that the enhanced perioperative care and health protection (EPOCH) program added on to usual care reduces postoperative surgical site…
Consumption of foods containing L-arabinose will improve glycaemic and insulinemic response.
It is hypothesized that this mobile intervention will effectively reduce alcohol consumption and binge-drinking frequency.
To assess whether individualized feedback of self-reported PrEP medication adherence increases subsequent PrEP use, as measured by tenofovir levels in dried blood spots, in participants using daily PrEP.
We postulate that faecal microbiota transplantation (FMT) from obese donors in patients with cancer can improve satiety (appetite) and subsequently nutritional status. Secondly, FMT might restore the gut barrier function and hence reduce systemic…
Post-donation iron supplementation will be an effective strategy to enhance the iron status recovery in whole blood donors with low ferritin levels.
Due to its ability to avoid preterm birth, the neurodevelopmental sequelae of preterm birth could also be prevented by progesterone. However, progesterone may also exert direct effects on the fetus’ developing brain.
Oral bisphosphonate supplementation or the MMR vaccine can be used as immune potentiators when simultaneously administered with BCG, to further amplify the BCG-induced trained immunity response and maximize potential protective effects against COVID…
We hypothesize (hypothalamic) obesity can be treated with GLP-1 analogues in patients with craniopharyngioma.
Intake of 30ml Montmorency tart cherry juice twice a day during 4 weeks will reduce MCP-1 mRNA expression in omental adipose tissue.
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BCG vaccination may induce (partial) protection against susceptibility to and/or severity of SARS-CoV-2 infection. This will lead to reduced workplace absenteism under health care workers taking care of patients with COVID-19
Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.