Intake of 30ml Montmorency tart cherry juice twice a day during 4 weeks will reduce MCP-1 mRNA expression in omental adipose tissue.
Bron
Verkorte titel
Aandoening
(Morbid) obesity, chronic inflammation, (morbid) obesity related complications
Ondersteuning
Onderzoeksproduct en/of interventie
Geen registraties gevonden.
Uitkomstmaten
Primaire uitkomstmaten
The effect of Montmorency tart cherry juice on MCP-1 mRNA expression in omental adipose tissue.
Achtergrond van het onderzoek
Rationale:
Chronic inflammation plays a pivotal role in the development of morbid obesity and its complications. In the adipose tissue of patients with morbid obesity an abundance of pro-inflammatory adipokines and macrophages can be found. Dietary supplementation of anthocyanin flavonoids can reduce oxidative stress and inflammation and may provide a means to reduce these adipose tissue changes in morbid obesity.
Objective:
The objective is to study the effect of tart cherry juice on adipose tissue markers of oxidative stress, inflammation and macrophage infiltration, gene expression, visceral fat mass and analysis of the gut microbiome.
Study design:
Randomised controlled open label study. Measurements of subjects will be compared to their own basal values and controls.
Study population:
Adults with morbid obesity according to the IFSO criteria that are scheduled for laparoscopic gastric bypass surgery.
Intervention:
The intervention consists of 30ml cherry juice twice a day during 4 weeks.
Main study parameter/endpoint:
The main study parameter is MCP-1 measured in omental adipose tissue.
Doel van het onderzoek
Intake of 30ml Montmorency tart cherry juice twice a day during 4 weeks will reduce MCP-1 mRNA expression in omental adipose tissue.
Onderzoeksopzet
T0 baseline
T1 after four weeks
Biopsies during laparoscopic gastric bypass surgery
Onderzoeksproduct en/of interventie
All patients:
- DEXA scan at baseline (T0) and after 4 weeks (T1)
- Blood samples at baseline (T0) and after 4 weeks (T1)
- Stool samples at baseline (T0) and after 4 weeks (T1)
- Physical examinations at baseline (T0) and after 4 weeks (T1)
- Biopsies during laparoscopic gastric bypass surgery
Intervention group:
- 30ml Montmorency tart cherry juice (CherryActive, Active Edge Nutrition) twice a day during 4 weeks
Control group:
- 30ml placebo twice a day during 4 weeks
Publiek
Wetenschappelijk
Belangrijkste voorwaarden om deel te mogen nemen (Inclusiecriteria)
- Female sex
- Age 18-65 years
- BMI ≥ 35 kg/m2 and obesity associated illness or a BMI > 40kg/m2
- Qualified for laparoscopic gastric bypass surgery based on the IFSO criteria
- Positive advise from the Dutch Obesity Clinic (NOK)
- Positive advise from a bariatric surgeon
- Written informed consent
Belangrijkste redenen om niet deel te kunnen nemen (Exclusiecriteria)
- Male sex
- Pregnancy
- Diabetes
- Age <18 years or >65 years
- Current infectious or inflammatory disease
Opzet
Deelname
Voornemen beschikbaar stellen Individuele Patiënten Data (IPD)
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Andere (mogelijk minder actuele) registraties in dit register
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In overige registers
Register | ID |
---|---|
NTR-new | NL8468 |
CCMO | NL703333.029.19 |