2336 resultaten
We hypothesize that depletion of carnitine occurs during infusion of oxaliplatin, due to increased renal loss. This secondary carnitine deficiency may contribute to the development of CIPN.
It is hypothesised that compared to waiting list control condition, participants in the intervention improve their diet and physical activity on the short (6 months after baseline) and long-term (12 months after baseline; when the participant…
Our hypothesis is that piperacillin/tazobactam, ciprofloxacin, co-trimoxazole and doxycycline are able to penetrate hepatic cysts.
We hypothesize that ID is an important factor in the limitation of exercise capacity in HFpEF. Systemic low-grade inflammation does not only lead to microvascular dysfunction but also to iron deficiency. Iron deficiency has a direct effect on the…
The actual ERAS statement regarding intra- and postoperative analgesia recommends to not use thoracic epidural catheters in laparoscopic surgery anymore as a gold standard. This cohort study will investigate an alternative possibility of pain…
To compare a ventilation strategy that uses conservative targets (PaO2 55-80 mmHg (7.3-10.7 kPa)) with one that uses conventional oxygenation targets (PaO2 110-150 mmHg (14.7-20 kPa)) for arterial oxygenation. Primary endpoint is all-cause mortality…
Obesity is significantly associated with Atrial Fibrillation (AF), and, interestingly, if obese patients loose weight, AF dissapears in 50% of the cohort. On the other hand, adipose tissue (AT) functioning alters up weightchange. Therefore we…
We hypothesize that ESD will be associated with longer procedure times but lower costs. For lesions that prove to be benign, we hypothesize that ESD will lead to a higher number of R0 resections and lower recurrence rates, particularly for lesions…
We expect that treatment with azelastine/fluticasone propionate will decrease exercise tolerance limitation and will improve quality of life.
The use of higher field strength MRI-scanners will improve the detection of (small) structural brain lesions in patients with focal drug-resistant epilepsy, potentially resulting in better seizure outcome after resective epilepsy surgery.
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
Crohn’s disease (CD) is a chronic inflammatory bowel disorder (IBD) with a major impact on quality of life. Mucosal healing is an important treatment outcome to prevent long term complications of the disease. Regulatory M2 type macrophages play a…
The use of structural biomarkers (e.g. fundus autofluorescence imaging, optical coherence tomography or a combination thereof) may show a much more gradual progression that is indicative of functional vision loss at a later stage.
A structured use of clincal features in combination with bloodtests applicable as point-of-care(POC) tests, can improve recognition and outcome in sepsis patients
Addition of alternative tests (TEG/ROTEM® and/or TGA) which reflect the whole hemostatic status of a patient might help recognizing the level of thrombin formation and fibrinolysis and improve care in ECMO patients and potentially reduce the risk of…
Physicians will speak of an 'asthma cough' and while coughing is one of the symptoms of asthma, the specificity of coughing as a predictor for asthma is known to be low. It is hypothesized that the coughs and it's derived parameters,…
Postoperative change in deltoid volume following reverse shoulder arthroplasty is related to functional outcome
Gut-homing lymphocytes play a role in the development and maintainence of perianal fistula in Crohn's disease patients.
Treatment of ST-elevation myocardial infarction (STEMI) by means of mechanically reperfusion is often accompanied by reperfusion injury. As pre- and postconditioning in STEMI appears to be ineffective, cardioprotection should occur in parallel (…
Our primary objective is to compare the short and medium term (up to 6 months) clinical results in pain and function of the Bauerfeind SecuTec OA brace with only conservative treatment (no brace) in the management of patients with medial knee OA and…