2258 resultaten
• Characterize the plasma and Cerebrospinal Fluid (CSF) time concentration profile of 2-AG, 1-arachidonoylglycero (1-AG) over 24h and 16h period, respectively. • Determine the optimal sampling frequency of 2-AG, 1-AG for future studies. • Establish…
To investigate the trajectories of cognitive and adaptive functioning in adults with epilepsy and ID. In doing so we are looking for clinical determinants of cognitive and adaptive decline. Furthermore, the association between decline and serum…
We hypothesize that preoperative initiation (7 days before surgery) and perioperative continuation (until day 2 after surgery) of empagliflozin 10 mg daily (10 days total) will reduce the postoperative concentration of NGAL in plasma on…
This study aims to prove bio-equivalence pre- and post-rotation and therefore validate the standard of care clinical practice regarding the rotation from subcutaneous to transdermal administration of fentanyl in the Erasmus MC on PK and PD endpoints…
We hypothesize that success rates in terms of complete ablation rate will be comparable across the techniques and that only minor complications will occur in ≤10% of all patients. We mainly expect differences in patient satisfaction because of…
Semi-automatic views contribute to the ease of use and efficiency of the procedure.
The current implementation status of the IOTA-models is suboptimal and below the target of 80%. The research will provide insight in the exact implementation status of the IOTA-models in The Netherlands and impeding and promoting factors for…
Active surveillance is safe in patients with oesophageal cancer and a clinically complete response after neoadjuvant chemoradiotherapy outside the SANO trial.
Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
We hypothesize there is a difference in CPM between the protocols
Wij stellen de hypothese dat een ontstekingsremmend voedingspatroon (AIDP) een gunstig effect heeft op het darmmicrobioom (diversiteit en permeabiliteit), waardoor het globaal functioneren (gemeten met Outcome Questionnaire 45, OQ-45) en de…
We hypothesize that PARP inhibitors can potentiate radiation-induced tumor cell death in patients treated with PRRT. To determine the maximin tolerated dose (MTD) of this combination, a phase 1 dose-escalation study is needed.
• There is no difference in number of bonding failures between the direct and indirect bracket bonding methods • Patients favour indirect bracket bonding over direct bracket bonding • Brackets bonded with the indirect bracket bonding will have less…
Short hydration during cisplatin chemo radiation is significantly more effective than long hydration in preventing acute kidney injury
We expect that STRAVA users who will stop with using the self-tracker will experience body empowerment, while people who are using no self-tracker and will start using STRAVA will experience body alienation.
To explore, whether markers of mitochondrial dysfunction measured in isolated PBMCs or immune cell subpopulations differ between subjects with mitochondrial disorders and cardiomyopathy and healthy volunteers.
The goal of this trial is to investigate whether (and at which dose or ratio) CBD has a modulating effect on the psychotropic effects of THC by comparing the effects of THC to the combination of THC with CBD in a range of ratios. Simultaneously,…
Blue light glasses can manipulate (i.e., inhibite) body melatonine production to re-adjust the circadian rhythm of shift workers, thereby having the potential to enhance viglance, cognitive function, and positive mood during night shift work.
We hypothesize that PHA-022121 will be more effective in both the treatment and prophylaxis of acute angioedema attacks in patients with acquired C1-inhibitor deficiency when compared to placebo.
Two doses of the Coronavirus virus-like particle subunit vaccine ABNCoV2 in SARS-CoV-2-naïve healthy adults is safe and well tolerated.