494 resultaten
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
The main hypothesis is that specific mechanisms of action and level of immunosuppressive medication is the most important determinant of SARS-CoV-2 immunity after vaccination or infection in ISP patients.
The quality of life of adult patients with NMD can be enhanced by providing capability care in comparison to usual care.
Primary Objective: • To investigate whether or not persistent complaints and poor outcome after mTBI be explained by an interaction between physiological and psychological factors. In other words, the aim is to investigate whether a more optimal…
Het doel van dit project is om een methode te ontwikkelen waarbij al in de ambulance duidelijk wordt of iemand een beroerte heeft en zo ja, wat de oorzaak van die beroerte is (een hersenbloeding of herseninfarct). In project CINTICS willen we daarom…
The detection rate of the ICG method to identify the SLN in breast cancer patients is not inferior to the standard 99mTc method.
We hypothesize that the fertility enhancing effect of OSCM during HSGs is also present during THL.
The objective of the PANDORINA trial is to evaluate the non-inferiority of omitting routine intra-abdominal drainage after DP on postoperative morbidity (Clavien-Dindo score ≥ 3), and, secondarily, POPF grade B/C.
Primary Objective: To investigate whether timely delivery of iCBT will lead to a significantly lower mean fatigue severity score (CIS-fatigue) across follow-up visits (T1 and T2) as compared to care as usual. Secondary Objectives: To investigate…
Het primaire doel is te onderzoeken of macrofagen van AGN patiënten T-cel activatie en migratie induceren door een pro-inflammatoire fenotype.
Het doel van deze prospectieve gerandomiseerde, dubbelblinde, placebo-gecontroleerde studie is het evalueren van de pijnstillende effecten van preoperatief PECS-II-blok naast algemene anesthesie voor borstsparende chirurgie in vergelijking met een…
Major burns encompassing more than 15-20% of total body surface area (TBSA) induce a pathophysiological stress response and thereby massive inflammatory response. Patients with major burns develop metabolic changes and burn induced hypermetabolism,…
Ons doel is om de effectiviteit van optimaal gedoseerde MTX versus placebo te onderzoeken in patienten met recent gediagnosticeerd PMR (volgens de 2012 EULAR/ACR criteria).
As this is an explorative design, no formal hypothesis is made. However, our sample size is based on a difference of 2.5% or more in cumulative incidence of serious infections when continuing IA, hypothesizing that patients who continue their IA in…
Primair: Bepalen van de verandering in albumine:creatinine ratio in eerste ochtendurine van begin tot eind van de behandeling. Secundair: Bepalen van veranderingen ten opzichte van baseline in: - Systolische bloeddruk - Lichaamsgewicht…
Treatment with Venoruton prevents RVO, which is a surrogate outcome of PTS.
It is feasibility to introduce sleep and activity wearables in hip fracture patients (75+) during hospitalization
In deze studie willen we de klinische effectiviteit van interventie met slimme technologie (hartfalenbox) meten in hartfalenpatienten die bekend zijn op de polikiniek cardiologie in het LUMC.
We hypothesize that the inter-observer variability of the CPR, MCA, UA and UtA measurement will be less than intra-observer variability due to normal biological variation of cardiovascular control.
The present study aims to evaluate efficacy and feasibility of an online group intervention for parents of children with cancer that focuses on the specific issues that play a role in parents coping with a child with cancer. Hypothesis: Participants…