4762 resultaten
We hypothesize that depletion of carnitine occurs during infusion of oxaliplatin, due to increased renal loss. This secondary carnitine deficiency may contribute to the development of CIPN.
We hypothesise that the diet over time has become healthier and more sustainable. Our current study was set up to (1) identify the differences in food consumption and nutritional quality over the course of 20 years in the Netherlands using the…
It is hypothesised that compared to waiting list control condition, participants in the intervention improve their diet and physical activity on the short (6 months after baseline) and long-term (12 months after baseline; when the participant…
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the e-support program for parents of children with a chronic kidney disease; 2. to identify outcome measures most likely to capture potential patient…
Our hypothesis is that piperacillin/tazobactam, ciprofloxacin, co-trimoxazole and doxycycline are able to penetrate hepatic cysts.
The study of determinants of cardiovascular disease (CVD) is important because it provides insight in risks and opportunities to reduce the burden of CVD. A major gap in our current knowledge about CVD lies in the way we measure these determinants,…
Het doel van de studie is om op de consultatiebureaus in de regio Kennemerland de haalbaarheid, kosten-effectiviteit en acceptatie van vroege opsporing naar coeliakie (door middel van case finding) bij kinderen tussen de 12 maanden en 4 jaar te…
Changing the context in which individuals make lifestyle choices has a sustained impact on the dietary intake and cardiometabolic health.
Laparoscopic gastrectomy will result in a lower post-operative burden by means of shorter post-operative hospital stay
The hypothesis of this study is that dosing everolimus 5mg twice daily(BID) instead of 10 mg once daily (QD) decreases the incidence of side effects, as a result of a lower Cmax while maintaining Cmin and AUC.
The constantly increasing number of aorto-iliac lesions in patients with end-stage renal disease (ESRD) seems to be the result of three main factors: increased recipient age, frequent atherosclerosis accompanying with end-stage renal disease and…
The aim of this present diagnostic study is to determine the accuracy by which we can detect residual disease after neoadjuvant chemoradiotherapy.
Submucosal irrigation with the Gum Irrigator will reduce bleeding on probing, pocketdepts and the amount of anearobic bacteria in the non-surgical treatment of peri-implantitis.
In the Netherlands, case managers play an essential role in the care chain for people with dementia living in the community. Because the profession has just been started, there is a lack of evidence-based practice to provide treatment for agitation…
The mean 12 months eGFR change between adult HIV-1 patients on TDF containing cART without reported NSAID/MRP4-i exposure will be greater than HIV-1 patients on TDF containing cART in the highest quartile of monthly cumulative DDD NSAID exposure (…
Compression therapy is not necessary after VNUS. Patients receiving no compression therapy after VNUS will have similar outcomes in post-operative pain, oedema, and HRQOL, post-operative complications, time to full recovery.
- It is hypothesized that a tailored, outreaching and systemic intervention promotes medication adherence - It is hypothesized that a tailored, outreaching and systemic intervention has a beneficiary effect on other medical as well as psychological…
After epilepsy surgery an improvement of the sleep quality and structure can be expected as result of the disappearance or decrease of the daytime and or nocturnal seizures and the reduction of the amount of medication. After implantation of vagus…
We want to determine the influence and safety of probenecid on sorafenib pharmacokinetics. By inhibiting the OAT6 transporter there might be a faborable effect on Hand-foot syndrome
(Experimental) participants who receive information about the availability and use of mindfulness-apps after an MBSR course: (1) report higher frequency of mindfulness practice, (2) report higher mindfulness, lower general psychopathology, and…