30 resultaten
We hypothesize that in patients with severe corticosteroid dependent asthma Dabigatran etexilate will: 1. Reduce airway inflammation; 2. Improve asthma control and pulmonary function; 3. Reduce hypercoagulability in the airways.
Pain Rehabilitation Programs (PRP’s) are proven effective for patients with chronic musculoskeletal pain (CMP). Evidence about the relationship of dose on the effect of PRP however, is unavailable. We hypothesized that shortening PRP will not be…
Secondary cytoreductive surgery added to chemotherapy will increase progression free survival in selected patients with first platinum sensitive recurrence of ovarian cancer with a minimal negative effect on their health-related quality of life.
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
to further evaluate and monitor the safety and performance of the “BasIQ-4®” in a population of women delivering in general hospitals in The Netherlands when used as intended
A nursing nutrition intervention improves protein and energy intake and performance based on hand grip strength compared to usual care.
Children with chronical abdominal pain and small intestinal bacterial overgrowth supplemented with probiotics will show less abdominal pain compared to placebo.
Predominantly sleeping in the non-supine position could improve oxygenation and thereby shorten the disease course in admitted COVID-19 patients.
SARS-CoV-2 is present in the cerebrospinal fluid of COVID-19 patients with acute respiratory failure
Primary objective: - To evaluate the safety and tolerability of NT-0167 in healthy volunteers Secondary: - To evaluate the pharmacokinetic (PK) profile of NT-0167 in healthy volunteers after the administration of single ascending (SAD) and multiple…
Treatment with chloroquine or hydroxychloroquine of adult patients admitted with moderate to severe COVID-19, a NEWS-2 score ≤5, reduces the proportion of patients who show progression of their disease defined as a NEWS-2 score ≥ 7(22), admission to…
A subset of rheumatoid arthritis (RA) patients harbour antibodies against several post-translational modifications and are frequently positive for rheumatoid factor. The exact pathophysiology of the development of the autoantibody response and of RA…
To determine whether a second dose of IVIg in GBS patients with a poor prognosis improves functional outcome after 4 weeks. Secondary outcomes include functional outcome after 8, 12 and 26 weeks, duration of mechanical ventilation, length of…
Caregiver mediated exercises next to usual therapy will improve functional outcome for adults with stroke in gait, gait related abilities and ADL with a reduced length of stay (LOS) when compared to usual care alone. In addition we hypothesize that…
We hypothesize that FMT from a healthy donor will modulate the microbiome of the pouch of patients with ulcerative colitis, and will thereby resolve the inflammation of the pouch.
Bilateral cochlear implantation in children has potentially an advantage over unilateral cochlear implantation in terms of communication development (both preverbal communication and language development) and sound localization. This study will…
It is hypothesized that the FitMáx© questionnaire is a valid clinical assessment tool for CRF compared to the gold standard, a cardiopulmonary exercise test. Moreover we believe the FitMáx© to be fairly accurate in the preoperative risk assessment…
Contrast-enhanced ultrasound with microbubbles will localize the same axillary lymph node as Technetium-99m nanocolloid.
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The aim of the study is to assess whether in women with early PPROM tocolytics improve perinatal outcome.