6054 resultaten
If not well treated rheumatoid arthritis (RA) can lead to severe joint damage and subsequently functional impairment. Current treatment strategies aim at quickly lowering disease activity in order to prevent later damage. RA treatment…
The main hypothesis is that normo-ovulatory women with a deleterious BRCA mutation have lower levels of AMH compared to normal controls, with at least a difference of 0.90 ng/ml, suggesting an effect size of approximately five years in menopausal…
Reversibility of oral direct factor Xa inhibitors rivaroxaban and apixaban will be the same when a lower dosage of prothrombin complex concentrate (Cofact®) is used. Infusion with doses of 37.5 or 25 units/kg of PCC would be able to reverse the…
A subset of patients with ulcerative colitis have disease limited to only the rectum. Most patients will reach remission with conventional 5-ASA or corticosteroid treatments. However, there have been few studies investigating treatment options in…
Since bleeding risk is high in the elderly we hypothesize that clopidogrel is superior to ticagrelor and prasugrel in terms of causing lesser bleeding events and being non inferior in net clinical benefit in patients above 75 years and CRUSADE…
1. DBD adolescents will show diminished fear conditioning as compared to HCs in the basic condition, and this phenomenon is associated with altered function, connectivity and structure of brain areas known to be involved in fear conditioning. 2. DBD…
A low peak E2 during COS is considered to be safer than a high peak E2 in women with breast cancer
The primary hypothesis is that tubal patency test by a HyFoSy procedure is less painful compared to tubal patency test by a hysterosalpingography.
Improved understanding of slow conducting anatomical isthmuses in Tetralogy of Fallot and cryoablation of these slow conducting anatomical isthmuses during pulmonary valve replacement might prevent VT re- and occurrence.
We will develop a bi-daily low-dose metronomic treatment schedule with paclitaxel in a convenient oral formulation and test whether this therapy has significant anti-angiogenic and anti-tumor activity.
Supplementation with omega-3 LCPUFA from krill oil in healthy adolescents will result in: - improvement of the omega-3 index - improved cognitive performance - improved mental well-being - better academic achievement
Study I: To assess the bioavailability of Zinc from milk (1), fortified milk (2), a supplement (3), and from raw milk (4). Study II: To assess the effect of milk on Zn absorption from intrinsically labelled rice
Atrial fibrillation (AF) is the most common cardiac arrhythmia with a prevalence of 1-2% in the general population, increasing with age. It is associated with a 5-fold increased risk of stroke if untreated. While anticoagulant agents are effective…
To determine whether sunitinib rechallenge in patients with mRCC, who had benefit (defined as stable disease for at least 6 months) from prior treatment with sunitinib and who progressed on both sunitinib and second-line therapy (or were without…
Estrogen plays an role in the dynamic changes in bone marrow adiposity.
The immune response to pneumococcal vaccination in patients after community acquired pneumonia with S. pneumoniae is different compared to pneumonia patients with another pathogen.
A failure to signal the salience, and especially the anticipation of positive events, is thought to be at the core of social-emotional apathy (SEA) in patients with schizophrenia. This salience system is highly dependent on dopamine from the…