3568 resultaten
This study is a phase I trial, testing the safety and toxicity of allogeneic NK cell infusions with an escalating dose of ex vivo expanded NK cells following immunosuppressive conditioning therapy in elderly patients with AML.
Tumour cell disruption by radiation generates a surplus of neo-antigens that enhances the effect of immunotherapy in solid malignancies as well as malignant lymphomas. The hypothesis is that the combination of immune checkpoint inhibitors and…
We hypothesize that rectal NSAID prophylaxis use will have significantly risen in comparison to the 2013 survey. We hypothesize biliary endoscopists will show a significantly better risk factor recognition than general gastroenterologists. We…
1. Personalised tools and technologies help to stimulate an increased compliance to a healthy lifestyle in people with overweight and/or obesity and who are cardio-metabolically compromised. Increased compliance may (eventually) lead to a more…
We hypothesize that the ingestion of quark will increase post-prandial muscle protein synthesis at rest in both young and older men. In addition, we hypothesize that exercise will augment the post-prandial muscle protein synthetic response to quark…
Recent research shows that obesity is associated with changed bowel flora composition with a relative abundance of the two dominant bacterial divisions, the Bacteroidetes and the Firmicutes. Interestingly, this specific bacteria associated condition…
We expect that planned visits at the outpatient clinic are unnecessary due to low percentage of treatment changes. Furthermore, we expect that treatment changes will appear at unplanned visits.
The level of AGEs can predict response to intravitreal anti-VEGF therapy in DME
The primary research questions are: 1. To what extent does a 4 week ReHab-TOAT regime lead to improvement of arm function in chronic stroke patients with either a severely or moderately affected arm-hand? 2. To what extent is any improvement of arm…
Our main objective is to investigate whether an augmented CBT leads to the reduction of depression and anxiety symptoms in stroke patients. We will compare the outcomes of this experimental treatment with a control intervention (i.e., computerized…
We think that not every patient with a paracetamol intoxication might need the high dose of acetylcysteïne antidote we are used to dose in the Netherlands
We hypothesise that patients in the intervention group will show a reduction in sedentary time of at least 60 minutes per day after the cardiac rehabilitation program, compared to a reduction of maximally 30 minutes per day in the control group.
It is hypothesised that the preschool-based intervention will improve the ECEC teacher-parent partnership regarding eating, physical (in)activity and sleeping behaviours in children. The intervention should reach parents and their children with…
Lung transplantation patients are immunocompromised due to antirejection therapy. The effectivity of the COVID-19 vaccination in this high-risk patient group is completely unknown.
1. We hypothesise that the G-POEM (endoscopic pyloromyotomy) will be an effective and feasible technique as treatment of delayed gastric empyting.
helicopter transport can be done safe without changes in vital signs
We aim to use Epstein-Barr Virus (EBV) within nasopharyngeal carcinoma (NPC) tumour cells as therapeutic target. In these cells EBV “hides” in a latent state due to methylation of the viral promoters, expressing only few non-immunogenic viral…
Asthma patients experience more anxiety during COVID-19 compared to a stable timepoint in the past.
The hypothesis is that methylation marker panel, potentially combined with additional biomarkers, can predict (non-)regression of HGAIN, thus determining the need of immediate treatment versus active surveillance, and the safety of withholding…
We hypothesize that ACT guided heparinization will result in a decrease of thrombo-embolic complications, without a significant increase in bleeding complications when compared to the use of a non-ACT guided standardized bolus of 5 000 IU. The…