877 resultaten
The hypothesis of the present study is to demonstrate that detection of a particular pattern (e.g., persistent vs. non-persistent) of myocardial (alpha)V(beta)3/5 expression by scintigraphy imaging at 3 and 8 weeks after MI can be used to determine…
1. It is hypothesized that participation in the Active plus program contributes to an increase in physical activity behaviour among older adults; 2. Additionally receiving physical and social environmental information results in an extra increase…
ARA290 will reduce disease activity in rheumatoid arthritis.
Therapeutic footwear of which adequate off-loading properties are guaranteed and monitored by dynamic plantar pressure assessment will result in a reduced plantar re-ulceration rate in diabetic patients with prior plantar foot ulceration compared to…
Older people with dementia who participate in a combined aerobic and strength training program will show larger effects on cognition, physical functioning, ADL functioning and social functioning in comparison with older people with dementia who…
We propose that kinase activity profiling may be a potential clinical diagnostic tool to predict for tumor response to targeted therapy with tyrosine kinase inhibitors (TKI's).
The pharmacotherapeutic treatment of patients with cancer is generally associated with multiple side-effects. The cause of the side-effects is usually due to the toxicity of the drugs themselves. In addition, drug interactions can intensify side-…
The measurements of overnight SpO2 and/or gas mixing and/or overnight cough might be useful in CF patients aged 0-4 years old. In this age group, standard spirometry can not (yet) be performed. As a consequence, there currently are no measurements…
There are significant differences in the quantitative data for the groups of normally sigthed and visually impaired children older than 6 years. The hypothese is that is also for children from 2 until 6 years.
Occupational rehabilitation with a gradual return to work based on the principles of exposure in vivo will be more (cost)effective in reducing absenteeism than usual occupational rehabilitation.
In 2003 the number of chronic heart failure (CHF) patients in the Netherlands was estimated at 180.000. It is expected that ageing of the population in the Western world will dramatically increase this number in the near future. The management of…
On the basis of the available literature, we hypothesize that the clinical and cost effectiveness of computerized cognitive-behavioural therapy with limited therapist support is not inferior (by an amount of delta = 0.2) to face-to-face therapy…
The use of parenterally administered LEV in neonatal epileptic seizures, detected electrographically, with or without clinical signs, will be safe, and pharmacokinetic and –dynamic properties of the use in neonates will be determined.
Particularly in patients at risk, the stress-management intervention affect self-reported, immune and neuroendocrine indicators of stress reactivity.
Neurostimulation can improve collateral perfusion measured as a Pw/Pa ratio, during acute coronary occlusione.
Lapatinib inhibits the function of Cytochrome P450 3A isoforms and P glycoprotein.
Evidence based medicine is the standard for current clinical practice. Guidelines and decision rules are developed to support medical decision making. Application of decision rules are supposed to improve efficiency and quality of care by early…
Locoregional anesthesia does not work as well in patients with the Ehlers-Danlos syndrome as in people who do not have this syndrome.
To determine the effect of an early MRSA detection strategy on nosocomial MRSA infections in a cohort of surgical patients at a large teaching hospital.
To determine if zinc supplementation in AMD patients has a direct measurable effect on the complement system explaining the mechanism through which this substance exerts its influence on AMD progression.