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Screening causes a difference in prostate cancer mortality of 20% or more.
Previous trials showed that both doxorubicin and thalidomide have anti-tumor activity against hepatocellular carcinoma (HCC). There are indications that these two agents interact synergistically and have non-overlapping toxicity profiles. This trial…
Enzyme therapy with recombinant human alpha glucosidase results in prolonged survival; improvement or stabilisation of cardiac hypertrophy and function, improvement or stabilisation of pulmonary function and improvement or stabilisation of muscle…
The hypothesis is that infants who receive the Infant Behavioral Assessment and Intervention Program (IBAIP) will be able to regulate themselves better and that disabilities will therefore be prevented or develop to a less serious degree.
Resuscitation after birth with 30% oxygen reduces oxidative stress and is safe in preterm infants.
In a randomized controlled study comparing psychiatric consultation with care as usual by the company physician, patients will improve in the intervention group in terms of duration of sick leave, general functioning and quality of life.
10 Gy additional boost to the tumor bed will yield an increase in local control at 10 years from 88% to 93%, with still acceptable cosmesis.
The hypothesis is that cummulative doses of 2.5, 5.0 or 7.5 gram methylprednisolone infusions are equally effective in moderately severe Graves' ophthalmopathy, but that the doses differ in the number and severity of side effects.
Due to tumoricidal effect of PDT , it is expected that the central bile ducts remain free from tumor and so better and prolonged drainage can be achieved leading to beter QoL and survival.
Low molecular weight heparin plus aspirin reduces the recurrence of preeclampsia and/or small for gestational age infants before 34 weeks gestational age in women with documented thrombophilia with a history of preeclampsia and/or small for…
1. Can a larger percentage of Low SES women with depressive and/or stress related symptomatology be reached with an intervention when this contains an exercise component? 2. How effective is exercise only (B) compared to a control group (C) and does…
The hypothesis to be tested is that the outcome in arm B is better than in arm A.
To provide evidence that restoration of euthyroidism (normal TSH) improves thyrotoxic symptoms and signs and quality of life and lowers the risk of subsequent atrial fibrillation and bone loss in subjects with endogenous subclinical hyperthyroidism.
1. In patients with a painful arc, treatment with hyaluronic acid and lidocaine, will give a mean improvement of 70 % of their pain at 26 weeks after start of the treatment with subacromial injection as compared to subacromial injection with a…
Test in a phase III randomised study whether an improvement of loco-regional control can be obtained with accelerated postoperative radiotherapy (66 Gy in 5 weeks) as compared to conventionally fractionated radiotherapy (66 Gy in 7 weeks) in…
1. What are the effects of a minimal intervention given by a nurse and a more intensive psychological intervention on managing fatigue during active treatment of cancer compared to no intervention? Will a minimal intervention be sufficient or is a…
Clients in a consumer-driven program for recovery, empowerment and experiential expertise will have better outcomes on self-efficacy and empowerment than clients on a waiting list for the program.
The treatment of depression in primary care: efficiency of computerised cognitive behaviour therapy.
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