33 resultaten
Hypertension causes subclinical and clinical damage in end organs. The exact manifestations of end organ damage in hypertension itself are unknown. The hypothesis is that differences in the cardiovascular risk profile in hypertensive patients are…
In order to validate the implementation and efficacy of a novel combination of a reward-learning and stress-processing paradigms, we conduct a computerized behavioural pilot study using healthy volunteers. In the reward-learning paradigm, the main…
Protein Supplement, used for extremely-low-birth-weight (ELBW) infants (< 1000 g) in addition to human milk and/or preterm formula in daily practice, is well tolerated and safe.
By combining Yttrium-90 radioembolization and Radiofrequency Ablation for treatment of patients with colorectal liver metastases, we might be able to target the remnant tumour cells in the rim of the ablation zone and improve the disease free…
Once an objective test of competence becomes available for research practice, non-competent children will no longer have to go through the full informed consent procedure. Competent children will be more actively engaged in that procedure, with…
A risk prediction model, using patient characteristics, early available clinical parameters, laboratory results and use of medication as parameters could reliably predict the risk of ICU-AW two days after ICU admission.
Individuals with a single, non-specific symptom are often identified with a genetic variation of unknown significance in de AlfaGalactosidase A gene that is involved in Fabry disease. This study aims to develop diagnostic algorithms to improve the…
We aim to assess gene expression patterns in cilia-producing cells from healthy controls to develop a candidate gene list for PCD. We hypothesise that: 1. Known PCD genes show similar gene expression patterns during ciliagenesis; 2. Novel candidate…
1. Patients with patent stents will have improved AVP and improved flow in CFV; 2. Patients with stent occlusion will have significantly higher AVPs and lower flow in CFV than patients without stent occlusion; 3. (Pain-free) walking distance will…
Augmentation of the maxilla with calvarial bone has a lower complication rate than iliac crest bone.
The goal of this study is to confirm the safety and efficacy of the Journey II BCS knee prosthesis by demonstrating non-inferiority of the cumulative percent success in subjects implanted with the JOURNEY II BCS Total Knee System compared to a…
Evalueren wat de gevoeligheid van de MSOT techniek is voor het meten van de doorbloeding en de hoeveelheid zuurstof in de onderbenen van gezonde vrijwilligers
In Gabon, antimalarial drugs are widely available in both the private as well in the public sector and often self-prescribed (correctly and incorrectly) for the many febrile episodes attributed to malaria. Insufficient facilities to check the…
This is a clinical trial in the home environment of 60 epilepsy patients to investigate the sensitivity and positive predictive value of a multimodal sensor system (‘LivAssured’) for the detection of nocturnal motor seizures.
It is generally accepted that the early-postoperative flow increase is indicative for successful maturation of an autologous arteriovenous fistula. Our hypothesis is that a patient-specific computer simulation model should be able to predict this…
Intraneural injection of anesthetics in upper and lower extremity blocks increases the risk of neurological damage.
Fentanyl is a strong opioïd and is highly lipophilic. Fentanyl pharmacokinetics are characterised by large inter- and intrapatient differences, which may have serious consequences for the activity and toxicity profile of this drug. The use of…
Information on the dynamics and shape of the device and how these change over time will improve our understanding about the fixation and/or sealing of the device, which may help in stent selection and in designing stent grafts that are more durable.
The Tegner and Lysholm scores can be used in the Dutch population to assess function and level of sportsactivity of patients after anterior cruciate ligament reconstruction.