6122 resultaten
It is postulated that the use of Osigraft will prove beneficial in the treatment of patients requiring decompression and instrumented lumbar spinal fusion while eliminating the pain and morbidity associated with harvesting of autograft bone from the…
Etanercept is able to improve clinical and functional abnormalities and to halt or reverse radiographic changes in inflammatory erosive hand osteoarthritis by virtue of blocking a major pro-inflammatory cytokine, tumor necrosis factor (TNF).
Ocular surface inflammation plays a pivotal role in dry eye and possibly in blepharitis. We hypothesize that the quantity of pro-inflammatory cytokines in tears and the expression of markers of inflammation on conjunctival cells are increased in…
Imiquimod, an immunomodulator, has been shown safe and effective in the treatment of external genital warts caused by low risk human papillomavirus (HPV). Therefore, it is hypothesized that this topical treatment may also be effective against…
Lithium treatment potentially enhances survival and slows disease progression in ALS patients
To evaluate the safety and tolerability of AP30663 in healthy males at doses up to 12mg/kg
2gr of Cefazolin is effective as prophylaxis for surgical site infections following implant removal below the level of the knee.
To investigate the effect of low dose oral silicon as an adjunct to calcium/vitamin D3 on markers of bone turnover and BMD.
Acute stress and increased levels of dopamine in the brain will lead to a shift from goal-directed behaviour to habitual behaviour. The shift will coincide with a change in functional connectivity between brain areas governing goal-direct and…
Primary: Upfront pre-treatment with a high bolus dosage of Tirofiban will result in a lower extent of residual ST segment deviation 1 hour after Primary Coronary Angioplasty for acute myocardial infarction, compared to no pre-treatment (besides…
The endocannabinoid system is involved in cognitive functioning, and therefore, challenging this system with THC will influence cognitive processing in humans. Moreover, subjects with cognitive impairments (i.e. psychiatric patients) will react…
The study products will result in different stool consistency compared to reference product
Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…
Topical benzoyl peroxide, applied on 5 consecutive moments by participants with positive baseline cultures for C. acnes, will reduce the number of positive skin cultures with 50% or more
A single, prophylactic dose of dexamethasone during cardiac surgery reduces the incidence of major postoperative complications.
Several open-label pilot studies have shown a promising effect of intrapyloric botulinum toxin injection on symptoms in severe gastroparesis. However, data from randomized, double-blind, placebo-controlled studies are not yet available. We intend to…
Amitriptyline ameliorates heartburn complaints in functional heartburn patients by modulating visceral perception.
We expect that the access-related intervention rate and medical costs will be reduced by 40% when correction of vascular access stenosis is triggered by clinically apparent access dysfunction rather than by asymptomatic flow reduction detected by…
We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status, which will eventually reduce the risk of coronary calcification.
A newly developed artificial saliva spray (Novospray) alleviates the feeling of a dry mouth in patients suffering from xerostomia better than placebo.