382 resultaten
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…
De zoete inval: zijn versuikerde eiwitten in voeding betrokken bij het ontstaan van type 2 diabetes?
Consumption of meals with a low advanced glycation endproduct content versus high advanced glycation endproduct content improves insulin sensitivity
Deep brain stimulation (DBS) targeted at the ventral anterior limb of the internal capsule (vALIC) is an effective treatment for treatment-refractory obsessive-compulsive disorder (OCD). However, effective DBS for these patients requires relative…
Saphenus blok reduceerd opname duur na epifysiodese van de knie - een triple blind superiority trial
We hypothesize that a single shot saphenous nerve block in combination with general anesthesia would be superior to general anesthesia alone regarding opiod consumption. pain scores. recovery and length of stay in adolecent patients undergoing…
We expect that treatment with azelastine/fluticasone propionate will decrease exercise tolerance limitation and will improve quality of life.
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
Crohn’s disease (CD) is a chronic inflammatory bowel disorder (IBD) with a major impact on quality of life. Mucosal healing is an important treatment outcome to prevent long term complications of the disease. Regulatory M2 type macrophages play a…
We hypothesize that probiotics with vitamin K2 producing properties can improve vitamin K status.
Failure of discontinuation of off-label antipsychotics in people with intellectual disabilities is the result of (1) subjective interpretation of behavior by caregivers, influenced by fear of worsening of behavior after drug reduction, (2) a…
We hypothesize that MTX and LEF combination therapy is superior to MTX monotherapy in patients with psoriatic arthritis
The primary objective of this pilot trial is to explore in patients with rheumatoid arthritis (RA) the difference between an intervention and a control group in change from baseline (T0) to at the end of a 4-week bright light therapy (T1) in the…
Our hypothesis is that preservation of the pectoral fascia may lead to a decreased seroma formation when compared to fascia removal, and has a beneficial effect on breast reconstructive surgery.
We hypothesize that endurance athletes receiving protein supplementation report a lower delayed onset muscle soreness score and lower muscle damage biomarker concentrations post-exercise compared to athletes receiving placebo supplementation.
Compared to placebo treatment with low dose amitriptyline or mirtazapine during 16 weeks will improve subjective insomnia in insomnia disorder patients in general practice.
Early introduction of an amino-acid based formula (AAF; Neocate® Syneo) in infants with non-IgE mediated cow's milk allergy (CMA) accelerates resolution of clinical symptoms compared to a whey based extensively hydrolyzed formula (eHF; Nutrilon…
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype among the autosomal dominant cerebellar ataxias, a group of debilitating, progressive conditions for which currently no disease-specific treatment ¨C i.e. aimed at the underlying…
The ingestion of free amino acids will result in higher plasma amino acid concentrations, resulting in enhanced muscle protein synthesis rates when compared with the ingestion of milk.
Leflunomide is able to reduce the relapses, the glucocorticoid use and the adverse events associated with glucocorticoid s use in PMR patients.
Evaluation of a novel alternative protein source to stimulate post-exercise muscle protein synthesis
We hypothesise that mealworm protein ingestion after unilateral resistance exercise will lead to significant higher rates of muscle protein synthesis in the trained leg compared to the untrained control leg. We also hypothesise that these rates will…