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Delegation of clozapine monitoring tasks to a Nurse Practitioner (condition A) is at least as safe as Treatment As Usual: physicians perform monitoring tasks themselves (condition B).
The aim of the study is to investigate the effect of conditioning with exogenous oxytocin on endogenous oxytocin release in healthy participants. We hypothesize that conditioning will lead to altered oxytocin levels.
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
Motivational interviewing has a positive effect on footwear adherence in diabetic patients at high-risk of foot ulceration.
In the current pilot-study, we will focus on demonstrating whether personalisation improves compliance with diet and lifestyle advice in a population of community-dwelling seniors. This advice will be based on personal preference, genotype,…
This study aims at demonstrating the effectiveness of IMR on the illness management skills and recovery of the patients. The added value for participants on different areas of life is examined. The research can contribute to answering the question…
In follow up measurements compared to pre-treatment measurement 1) WITHIN the treatment group there is a decline in the severity of PTSD symptoms and percentage of PTSD diagnoses; 2) BETWEEN treatment group and care-as-usual group there is more…
Surgical procedures are accompanied by high levels of distress and pain in the adult as well as the pediatric population. Music interventions have shown to reduce this anxiety and pain in adult populations. In this study, we will investigate the…
In this randomized, single blinded controlled trial, we evaluate the role of ketamine as an analgesic component of procedural sedation. We compare the effects of propofol-ketamine versus propofol-alfentanil and propofol-remifentanil for achieving a…
Custom made orthotic insoles by a podiatrist are (cost)effective in reducing pain and improving function in patients with plantar fasciitis compared to sham orthotic insoles and education alone.
We hypothesize that there is no difference in survival, clinical and radiological follow-up after >12 years of follow-up between the scarf and chevron osteotomy.
The hypothesis is that a combination of exercise therapy and splinting is superior to splinting alone in the treatment of patients with thumb base osteoarthritis.
primary: 1.CCT reduces rumination in depressed patients. secondary: 2. The effects of CCT on working memory effect generalize to other Working memory tasks (neutral and emotional). 3. CCT has an effects on the mood of depressed patients.
We hypothesize that iABM patients, relative to controls, will show less addiction problems, increased health, reduced physical and psychological complaints, and reduced use of health care post-intervention and at 6 & 12 month FU Further, we…
1. After completing real approach bias re-training, participants will show a stronger reduction in approach bias for alcohol than after placebo training (main effect 1); 2. After completing real attentional bias re-training, participants will show a…
Snare resection is non-inferior to hysteroscopic morcellation and snare resection is cost-effective.
When magnitude of the oro-sensory stimulation intensity and mastication are increased this will lead to an equal and additive reduction on food intake.
The aim of this study is to demonstrate that procedural sedation with propofol and esketamine is more effective and will result in less cardiopulmonary depression than sedation with propofol and the opioid alfentanil. Less side effects should also…