47 resultaten
To determine whether a strategy of invasive treatment (relative to continued medical treatment) of patients with type 2 diabetes mellitus, mild symptoms of stable angina pectoris, and documented myocardial ischemia lead to a decrease in cardiac…
90-day treatment with a selected probiotics mixture can reconstitute the microbiome diversity after antibiotic treatment for community-acquired pneumonia.
Patient with incurable disseminated left-sided colonic cancer are better palliated by colonic stenting than surgery measured by hospital free survival in "good health"(WHO-score 0 or 1) Colonic stenting is cost effective in patients with…
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Perioperative esmolol infusion titrated for heart rate control as an add-on to standard therapy including a long acting oral beta-blocker will improve heart rate control and decrease perioperative myocardial ischemia, without an increase in…
A family involvement program will reduce the number of unplanned readmissions in adult patients undergoing major abdominal surgery.
Secondary cytoreductive surgery added to chemotherapy will increase progression free survival in selected patients with first platinum sensitive recurrence of ovarian cancer with a minimal negative effect on their health-related quality of life.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
Half dose Urokinase (50.000IE/h) will significantly reduce hemorrhagic complications compared with the standard dose Urokinase (100.000IE/h) with comparable technical success rate
Multi-centre open label clinical trial.
Simvastatin (an HMG-CoA reductase inhibitor) induces apoptosis in vitro and sensitizes the myeloma cell to chemotherapy. This is the first clinical trial to test if in vivo there is the same sensitization in relapse or refractory multiple myeloma.
Does lipid accumulation in skeletal muscle and the heart effect mitochondrial function in relation to insulin resistance?
Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.
Chronic sleep disorders are associated with dysfunctioning during the day. Circadian rhythm disorders are a frequently occurring cause of chronic sleep disorders. The time at which the endogenous melatonin production starts to rise plays a key-role…
Multiple rounds of S(+)-ketamine infusions will give more profound and prolonged pain relief compared to a single infusion of S(+)-ketamine.
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We expect that preoperative and postoperative cooling will reduce swelling faster, reducing the time to surgery and time to discharge, respectively.