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Based on previous studies, we will expect that ambroxol improves neurological manifestations in patients with GD3.
A 10% point difference between the intervention group and control group in IDM is expected. The sample size calculation is based on a worst-case scenario with regard to precision. For a binomial distribution, the widest distribution and thus largest…
It is expected that the CFS patient gets more insight in his or her physical activity pattern, intentions develops to change the behaviour, and really changes the behaviour resulting in a reduction of the CFS complaints.
We hypothesize there is a difference in CPM between the protocols
A single PRP injection result in a clinical relevant reduction of the complaints at six months, compared to an injection with saline.
The induction of immunity might be slower in older persons than in younger individuals. This could influence the occurence of adverse events induced by the vaccine.
In the first 6 months Liraglutide affects weight more than CBT, but CBT provides weight maintenance after 12 months.
Breast cancer is the most common type of female cancer worldwide. Early detection has proven to have a positive influence on the prognosis and survival rate. An important aid in the detection and diagnosis of breast cancer is the use of medical…
fetal heart deformation and its development throughout pregnancy can be measured by speckle tracking. Fetal heart deformation might be different in pregnancies complicated by placental dysfunction.
To evaluate whether a dietary advice of green vegetables, beef and whole dairy products during six months including standard supportive care can decrease the TSH-level compared to standard supportive care alone in children aged 1-18 years with…
We hypothesize that depletion of carnitine occurs during infusion of oxaliplatin, due to increased renal loss. This secondary carnitine deficiency may contribute to the development of CIPN.
We hypothesize that treatment with peppermint oil will lead to a greater symptom (especially abdominal pain) reduction in IBS patients compared to placebo. This will lead to a higher total percentage of responders (as defined by FDA/EMA…
In line with results from recent pharmacological studies, it is expected that: 1. Inhibiting the cholinergic system by Inversine (Mecamylamine Hydrochloride) results in an impairment of disengagement, but will not affect bias; 2. Inhibiting the…
The administration of propranolol will inhibit the increase in dermal blood flow (DBF) induced by capsaicin application.
It is hypothesized that taste and smell disturbances are common among GIST patients using TKIs.
1. The primary research inquiry being raised concerns anaesthesia related causes: Is it possible that adapting an amount of Sevoflurane, from 1 MAC (minimum alveolar concentration) (2,5 vol%) to ½ MAC (1,25 vol%) in an MRI scan can reduce the…
Short hydration during cisplatin chemo radiation is significantly more effective than long hydration in preventing acute kidney injury
The aim of the pilot trial is to: 1. evaluate the potential effectiveness and effect size of the e-support program for parents of children with a chronic kidney disease; 2. to identify outcome measures most likely to capture potential patient…
To investigate the feasibility and safety of the DMUA-HIFU system for treatment of atherosclerotic plaques.
To study's primary objective is to establish the effectiveness of a low-threshold guided self-help intervention targeted at improving one's self image in people with anxiety and/or depressive symptoms and low self esteem. We expect to find…