53 resultaten
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
Ultrasound-accelerated catheter-directed thrombolysis can reduce the posttrombotic syndrome incidence, improve quality of life and reduce medical costs in patients with acute primary iliofemoral deep vein thrombosis.
Gaining knowledge on human responses against the influenza virus will help us in treating influenza infections and lead to more effective vaccines. Additionally, it might also lead to identification of individuals that have a high risk of morbidity…
1. The point of the skin with best possible transcutaneous nerve stimulation correlates with the point of the skin most superficial to the nerves stimulated within a range of 3 mm; 2. Ultrasound will reveal a significant number of sensitive…
We hypothesize that a treatment algorithm that is based on a simple validated measure of health status (CCQ) improves quality of life (as measured on a separate scale) and other classical COPD outcome measurement parameters such as exacerbation…
Public health authorities have recognized lack of hand hygiene (HH) as one of the important causes of preventable mortality and morbidity at population level. Both at national (UK, USA, Dutch VMS) and international levels (WHO) poor HH has been…
The hypothesis to be tested that the outcome in arm B is better than in arm A.
An effective intervention towards stopping passive smoke exposure in children is possible by means of an individualized program with repeated counseling, education, motivational interviewing, and by promoting parental awareness with feedback about…
The general objectives of this study is to test whether estrogens and androgens in both males and females affect cognitive functions and brain activity.
The hypothesis to be tested is that by consequent screening and subsequent treatment with optimized treatment strategies of patients with advanced cancer the quality of life and their communication with family can be improved. In addition, we…
Helium inhalation influences the coronary circulation and/or vessel diameter.
Consolidation of first line treatment of patients with transformed lymphoma with Zevalin of Zevalin-BEAM will prolong PFS.
By developing a model which predicts the risk of bleeding with coumarin use, patients can be treated more effectively, potentially avoiding the need for specific antidotes. Besides decreasing the risk of bleeding (potentially resulting in less…
Cervically applied TENS (transcutaneous electrical neurostimulation) might improve cerebral perfusion and therefore reduce the effectd of cerebral vasospasm afte SAH (subarachnoid haemorrhage).
A mathematically correct PK-PD model will be developed that describes the depressant effect of propofol on breathing with and without a background of remifentanil.
We hypothesize that, with increased arm abduction moment loading with a constant exerted abduction force, primary arm moment generators (deltoid muscle) will have a greater increase in activation (EMG) as compared to primary arm/glenohumeral…
The aim of this study is to determine the (cost)effectiveness of a home-based functional training programme as compared to regular physical therapy with regard to the ability to live independently and participation of frail elderly of 75 years and…
Assessment of feasibility of neoadjuvant chemotherapy consisting of docetaxel, cisplatin and capecitabine in resectable localized gastric cancer (stage Ib-IVa) and the introduction of the D1extra-lymphadenectomy as the standardized surgical…
The main objective of the present study is to evaluate (cost)effectiveness of Dementia Care Mapping (DCM)intervention in nursing home dementia care by performing a large RCT study.