289 resultaten
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
A combination therapy (MDT and TESIs) is effective and cost-effective compared to usual care among herniated nucleus pulpos patients with an indication for a lumbar herniated disc surgery
A strategy aimed to switch from INR-guided VKA therapy to a NOAC-based treatment strategy is superior to continuation of INR-guided VKA therapy with regard to the occurrence of major or clinically relevant non-major bleeding complications in frail…
Trends in and variability of vital signs reveal hidden information about the state and deterioration of the patient compared to absolute values of vital signs.
To study's primary objective is to establish the effectiveness of a low-threshold guided self-help intervention targeted at improving one's self image in people with anxiety and/or depressive symptoms and low self esteem. We expect to find…
Otosclerosis is an isolated ear disorder which can cause hearing and balance impairment. The cause of these symptoms is a disturbed bone metabolism confined to the area of the otic pit, the embryologic predecessor of the inner ear. Most patients…
To investigate whether the clinical outcome is similar after the implantation of the Resolute Integrity stent versus the Promus Element stent (non-inferiority test).
A Community One Health approach (bringing human and animal health together at the community level) improves disease surveillance efforts by Community Health Workers, health knowledge and behavior and physical health in study populations.
Improving treatment adherence (physical activity levels, unhealthy snacking consumption decrease, adherence to oral and insuline medication) through video-tailored eHealth communication strategies.
An ICT-supported, integrated, multidisciplinary treatment of COPD in primary care compared to usual care in primary care practices will improve the quality of life of COPD patients at an acceptable level of cost-effectiveness.
At the end of the study we should be able to publish an internationally accepted, multidisciplinary, evidence based guideline on the management of trigger fingers
Genestein inhibits the synthesis of heparan sulphate and can possibly slow down disease progression in Sanfilippo Syndrome patients.
We hypothesize that PESF improves aerobic and anaerobic performance in talented speedskaters.
Autonomy Enhancing Treatment (AET) is superior to Cognitive Behaviour Therapy (CBT) with regard to person-centred and comorbid outcomes (general psychopathology, depressive symptoms, autonomy-connectedness, self-esteem, quality of life ), and cost-…
We predict that the combination of the VR-GAIME and general aggression treatment will be more successful in reducing aggressive behavior.
To gain more insight into the pathogenetic processes involved in Sjogrens Syndrome(SS) bij analyzing the infiltrate and structural changes in salivary glands of SS patients and compare these findings to those in other (aspecific) inflammatory and…
Many studies described a niche (defect of the uterine scar) to be visible after a prior caesarean section (CS) by using ultrasonography. The exact moment when a niche can be visualized and the best moment to evaluate it is unknown; most studies…
Incisional negative pressure wound therapy reduces the amount of patients with clinically relevant surgical site occurrences within 30 days after contaminated abdominal wall reconstruction.
The study has the following (quantitative and qualitative) research questions: 1. To what extent (how much) does KASPAR contribute to reaching therapy/educational goals for children with autism spectrum disorder compared to care as usual? a. More…