255 resultaten
The null hypothesis of the primary outcome measure is that there will be no significant differences in DASH scores 6 months after surgery between patients who underwent plate fixation or intramedullary fixation with a TEN. The alternate hypothesis…
Based on the human milk composition, Nutricia Research has developed a new infant formula with a new fat blend, more similar to that of human milk. This new formula is currently being studied for safety and its effects on growth. The comparator used…
The hypothesis is that offering CBT in a group format while discontinuing antidepressant medication will reduce the high relapse rates in remitted anxiety disorder patients who discontinue pharmacological treatment.
In the present study we will investigate the pharmacokinetic profile of three doses of sublingual testosterone, and measure subjective and physiological measures of sexual functioning in healty premenopausal women. The lowest effective dose of…
HCQ causes both autophagy inhibition and chromatin modification, thereby (re)sensitizing tumor cells to EGFR TKIs, hypothetically increasing response rates after one week.
The purpose of this study is to demonstrate the added value of using 'LMA-S in the ambulance with CPR in the Netherlands indigent patients. The hypothesis is that the value of using the LMA-S is located in the safety and speed of placing the…
There is clear medical need in pediatric high-grade MDS and JMML to control disease pre-SCT without the disadvantages associated with intensive chemotherapy. So far no agents have been successfully applied in this window, or are specifically…
To determine whether doubling the dose of corticosteroid injections in the treatment of arthritis in knee joints is more effective, both in number of responding patients and in duration of response (pain relief).
NT-proBNP guidance during in-hospital treatment of acutely decompensated heart failure (to strive for >30% reduction) reduces readmissions and mortality and increases the number of days alive out of hospital in the first 180 days.
Subacromial disorders are considered to be the most common pathology affecting the shoulder. The optimal therapy for shoulder pain (SP) in primary care is yet unknown, since clinical history and physical examination do not provide decisive evidence…
We expect that parents involved in the program (as compared to controls) will be more involved in high qualitative communication on alcohol topics, have more confidence in discussing alcohol matters and greater efficacy to prevent their children…
High viscosity PMMA bone cement reduces the occurrence of cement leakage comprared to low viscosity PMMA bone cement.
We hypothesize that administration of intravenous atropine during induction of propofol/remifentanil may have a positive effect on the hemodynamic profile and peripheral and cerebral tissue oxygenation during and after induction of anesthesia.
We hypothesize that the new AFI-III system – compared to the conventional AFI-II – enhances the distinction between early neoplasia and inflammation in BO and thus reduces the amount of false positive lesions, allowing for targeted sampling and…
The aim of the present study is to investigate the possibility of the use of non-invasive methods for the evaluation of bladder outlet obstruction after ProACT device implantation by comparing non-invasive measurements with invasive measurements.…
The primary objective of this study is to analyse whether preventive hamstring exercises (Nordic Hamstring Curl) can reduce injury incidence in Dutch elite amateur soccer players. The secondary objective of this study is to analyse whether…
Antipsychotics (haloperidol) can cause acute changes in cardiovascular functions, metobolic parameters and platelet aggregation in elderly patients.
We hypothesise that the intervention group will significantly improve detachment by increasing daily physical activity and relaxation, compared to the control group receiving usual care (minimal intervention or company's current health…
We hypothesise that fasting-induced insulin resistance will result in decreased glucose uptake and activity of brown adipose tissue (BAT). In addition, prolonged fasting will lead to reduced mitochondrial uncoupling in skeletal muscle, which is…
Ultrasound-accelerated catheter-directed thrombolysis can reduce the posttrombotic syndrome incidence, improve quality of life and reduce medical costs in patients with acute primary iliofemoral deep vein thrombosis.