55 resultaten
Primary hypothesis: Octane concentrations in exhaled breath facilitate early detection of ARDS in ICU patients. Secondary hypotheses: - ARDS resolution is associated with a decrease in octane in exhaled breath. - Additional biomarkers of ARDS can be…
Our hypothesis is that in patients with no-option critical limb ischemia, a treatment with pDVA is a feasible, safe and a clinically effective approach.
We hypothesize that ID is an important factor in the limitation of exercise capacity in HFpEF. Systemic low-grade inflammation does not only lead to microvascular dysfunction but also to iron deficiency. Iron deficiency has a direct effect on the…
Intravenous immunoglobulin and intravenous methylprednisolone as optimal induction treatment in CIDP
Primary objective of this randomized controlled trial is to assess whether combining IVIg and methylprednisolone leads to more frequent long-term remission in CIDP compared to treatment with IVIg alone.
We hypothesize that in critically ill patients, measuring the anti-factor-Xa randomly in a 3 to 5 hours timeframe, may introduce a significant variation in the measured anti-factor-Xa and can seriously underestimate the real peak anti-factor-Xa.
Trifluridine is primarily metabolized through degradation by thymidine phosphorylase to the inactive metabolite 5-(trifluoromethyl)-uracil (FTY) without any involvement of the cytochrome P450 enzyme system. The primary route of excretion of…
Exploratory study investigating the efficacy of the currently recommended dosing regimen of ciprofloxacin prophylaxis in patients treated for haematological malignancies.
Fiducial markers placed on endoscopically determined tumor borders are a good surrogate for macroscopic tumor.
We hypothesize that dietary supplementation with seaweed will improve glucose regulation in T2DM patients.
It is an observational study, no null hypothesis has been formulated. The purpose of StEM is to understand the expectations, needs, experiences, choices and decisions of pregnant women and women who recently gave birth in the Netherlands, recording…
High-resolution ultrasound (HRUS) is a quick and cost-effective technique to study the morphology of peripheral nerves. Sonographic characteristics of plexiform neurofibromas and MPNST have been described in the literature. Recently, a pilot study…
Main question: Is Theraplay an effective treatment method for children with ASD and what is the effect of treatment with Theraplay on their parents? Prior RCTs proved that Theraplay leads, among other things, to a decrease in internalizing problem…
Awake craniotomy improves safety and efficacy during surgery for glioblastoma in eloquent areas
Individual-directed resilience training can reduce chronic stress and prevent burnout among students
The primary hypothesis for this data collection study is that there are various surrogate physiological parameters for inferring blood pressure (BP), which can be more easily obtained than the direct BP measurement. An example of such surrogate…
The present study will assess the composition of the oral microbiome in patients who have been referred to the NKCV (Nederlands Kenniscentrum Chronische Vermoeidheid) for treatment for complaints of severe and protracted fatigue. Objective…
EBUS/EUS-B sampling of mediastinal/hilar lymph nodes and/or primary lung tumors with the Acquireᵗᵐ 22G TBNB needle has a higher suitability rate for the assessment of PD-L1 expression in comparison to the regular 22G TBNA needle in patients with…
The aims of this research proposal are threefold: 1) to evaluate the accuracy of existing telephone scripts for triage purposes used by medical assistants for patients calling with symptoms of chest pain; 2) to evaluate the discriminatory properties…
We expect that people allocated to the online CBT condition will show larger reduction at post-treatment assessments in symptom-levels PCBD, PTSD, and depression compared to waitlist controls (Hypothesis 1). We expect that greater reductions in…
Topical benzoyl peroxide, applied on 5 consecutive moments by participants with positive baseline cultures for C. acnes, will reduce the number of positive skin cultures with 50% or more