72 resultaten
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
To evaluate the cost-effectiveness of therapies for male subfertility.
1. Active sniffing decreases appetite; 2. Food choice is mainly influenced by the food odour that was perceived first.
Sunitinib, when given in a high-dose, intermittent schedule, may exhibit improved efficacy with an acceptable toxicity profile.
Since bleeding risk is high in the elderly we hypothesize that clopidogrel is superior to ticagrelor and prasugrel in terms of causing lesser bleeding events and being non inferior in net clinical benefit in patients above 75 years and CRUSADE…
A low peak E2 during COS is considered to be safer than a high peak E2 in women with breast cancer
Individuals with a single, non-specific symptom are often identified with a genetic variant of unknown significance in the Alpha Galactosidase A gene that is involved in Fabry disease. Assessment of Small fibre neuropathy that is often present in…
One way of providing binaural cues to unilateral CI recipients is to wear an acoustic hearing aid in the contralateral non-implanted ear, known as bimodal hearing. The benefits of bimodal input (e. g. speech perception in noise, localisation,…
To reduce treatment-related toxicity in patients with localized prostate cancer, focal treatment is warranted. This can be achieved with MRI guided high-dose-rate brachytherapy. We expect that a single dose of 19 Gy to the tumour volume will be of…
Mindfulness training as well as medication will reduce symptoms of attention, hyperactivity and impulsivity, not only directly after training but also at follow-up.
An online intervention will be an effective intervention for treating affective symptoms in pregnancy and their complications by reaching more women and making therapy easier accessible
Vernakalant is superior to Amiodarone and rate control alone in the acute conversion of recent onset atrial fibrillation (AF) in critically ill patients admitted to the medical ICU.
Primary: are there differences between the online course group and the control group in the change in depressive complaints from baseline to follow-up measurements? Secundary: Is the intervention cost-effective compared to a no preventive…
“Personalized Prevention Approach for CardioMetabolic Risk” (PPA CMR), a prevention program for cardiometabolic disease (CMD) combined with an individualized lifestyle intervention, is effectiveness and cost-effectiveness when implemented in primary…
Endocuff colonoscopy will increase the number of adenomas detected.
In this observation study we hypothise an incidence of UTIs of 30% in the first year after starting CIC. Moreover we hypothise a marked reduction in quality of life and an increase in health care expensis in patients with UTI.
Renal artery denervation (RDN) on top of pulmonary vein isolation (PVI) will improve the success of ablative therapy for patients who have paroxysmal and/or persistent atrial fibrillation, with out of range hypertension (systolic >140 mmHg or…
The maternal diet is highly responsible for the composition of breast milk which will result in at least differences between cultures and geographical separated populations. The maternal diet and breastmilk composition will show off in the…
The introduction of ultrasound will give reduction of at least 25% in radiation burden on healthcare professionals in the pain clinic
The hypothesis is that immunization against VEGF will circumvent the specific drawbacks of the current anti-VEGF treatment modalities. The primary objectives of this study are to investigate the safety and tolerability of hVEGF26-104/RFASE and to…