936 resultaten
Primary aim: 1. To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users). Secondary aims: 2A. To…
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
- Smokers are implicitly biased with regard to the pros/cons of smoking (more attention and/or approach tendencies with regard to the pros) - These biases can be retrained using implicit pictorial trainings based on the Visual Probe Task and the…
A strategy aimed to switch from INR-guided VKA therapy to a NOAC-based treatment strategy is superior to continuation of INR-guided VKA therapy with regard to the occurrence of major or clinically relevant non-major bleeding complications in frail…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability. There are 3 research questions to be addressed: 1. Is longstanding, optimized active exercise therapy more…
1. Personalised tools and technologies help to stimulate an increased compliance to a healthy lifestyle in people with overweight and/or obesity and who are cardio-metabolically compromised. Increased compliance may (eventually) lead to a more…
We hypothesize that the ingestion of quark will increase post-prandial muscle protein synthesis at rest in both young and older men. In addition, we hypothesize that exercise will augment the post-prandial muscle protein synthetic response to quark…
- A standardized approach by a multidisciplinary experteam will evactuate a reduction of the use of restraints in care for people with intellectual disabilities
Previous trials showed that both doxorubicin and thalidomide have anti-tumor activity against hepatocellular carcinoma (HCC). There are indications that these two agents interact synergistically and have non-overlapping toxicity profiles. This trial…
The aim of this protocol is twofold. 1. Firstly, we aim to combine the new response monitoring method (PET imaging) with the present technique (dynamic CE-MRI imaging) in order to discriminate between favourable and unfavourable response of the…
There is a relationship between personality factors and prognosis (i.e., mortality; recurrence of disease), also after correction for tumor staging. Both personality and QOL play a role in the relationship between chemotherapy/radiotherapy and…
Primary Objective: 1.To investigate whether daily electrical stimulation of gluteal and hamstring muscles combined with usual care is more effective in reducing recurrences of PUs than only usual care in individuals with chronic SCI, who often have…
Pulmonary rehabilitation prior to bariatric surgery is effective by means of outcome (asthma control, complications, recovery, physical condition, quality of life) after the bariatric surgery.
The objective is to identify a formulation of ModraCape001 that will release capecitabine in vivo over a time-period of about 18 hours. We hypothesize that prolonged exposure, without a high peak exposure to capecitabine, improves the benefit/risk…
Early nutrition in preterm infants is essential for growth and neurodevelopment. The last decades more aggressive nutrition has been implemented in clinical practice to ensure optimal growth and thereby optimal neurodevelopmental outcome, as…
ARA290 regenerates growth of nerve fibers and gives improvement of illness.
Improving treatment adherence (physical activity levels, unhealthy snacking consumption decrease, adherence to oral and insuline medication) through video-tailored eHealth communication strategies.
The goals of treatment in Crohn’s disease have evolved in recent years from symptom control to healing of mucosal lesions, usually visualized by endoscopy. Potent therapeutic agents, such as anti-TNF agents, have made restoration of mucosal…
These patients are difficult to diagnose due to a multitude of non-specific symptoms and the lack of fast and specific tests. In this study we will be able to investigate patients that are admitted with acute abdominal complications and observe them…
A tracer coctail combining indocyanine green and radioactive colloids will allow enhanced detection of the sentinel lymph node in breast cancer patients.