253 resultaten
Gut-homing lymphocytes play a role in the development and maintainence of perianal fistula in Crohn's disease patients.
Intranasal administration of cobalamin can be used as an alternative for the standard intramuscular injection of cobalamin in cobalamin deficient patients.
To evaluate the impact of three different implementation strategies for implementing IBSM in current clinical practice, we have proposed the following three hypotheses: 1. Hypothesis 1 (Reach): More general practices will participate in IBSM in the…
The self-help intervention Happy@Work will reduce symptoms of depression. The self-help intervention Happy@Work will be cost effective.
Deep brain stimulation (DBS) targeted at the ventral anterior limb of the internal capsule (vALIC) is an effective treatment for treatment-refractory obsessive-compulsive disorder (OCD). However, effective DBS for these patients requires relative…
Parenting is essential for the upbringing of social, mentally and physically healthy children. Parenting interventions can support parents in this process. In general, parent training programs have a positive influence on various outcomes related to…
We hypothesize that peripheral perfusion targeted fluid management (PPTFM) might prevent excessive fluid administration, leading to less formation of tissue edema, less respiratory dysfunction and shorter duration of mechanical ventilation.
An intervention consisting of a set of specific fatigue reducing and health enhancing advices will lead to less fatigue and sickness absence in airline pilots. Following the intervention and the accompanying advices will lead to pilots reporting…
The purpose of the study is to conduct a randomised controlled trial with the onlinecourse 'Voluit Leven' as an intervention to study the: 1. Cost-effectiveness in terms of reduction of psychological symptoms (mood symptoms and disorders…
We want to establish an abbreviated, multidimensional, evidence based, diagnostic personalityprotocol within the mental health services. The hypothesis is that the mutidimensional testcombination of VTCI, NEO-FFI and CISS is sufficient reliable and…
Nicardipine might decrease adverse maternal and neonatal outcome due to its pharmacokinetics and fewer side-effects.
The overall aim of this study is to implement bariatric surgery including the multidisciplinary care pathway around the procedure for unsuccessfully treated adolescents with severe obesity in the Netherlands. Therefore, feasibility, efficacy and…
Given the high prevalence and burden associated with sexual problems and the existence of barriers to seek treatment among gynaecological cancer patients, there is a clear need for a brief, inexpensive and effective psychosexual rehabilitation…
We hypothesize that implementation of the new post-transplantation program will result in: - Decreased renal function decline (improved graft survival) - Improved medication adherence - Improved tacrolimus exposition - Improved feeling of patient…
It is hypothesized that the E-health self-management treatment results in lower impact of the disease on daily life, primarily a lower level of distress, in comparison to care as usual. As secondary objectives the effectiveness of the treatment on…
A constant Hb concentration will improve the quality of life of patiënts with a chronic need for bloodtransfusions.
Interferons (IFNs) are a family of cytokines which have important antiviral and antiproliferative properties. They also play an important role in immunomodulation. Type I IFNs have been implicated in autoimmune diseases, including systemic lupus…
Targeting a higher SpO2 (95% lower limit) in children with moderate-severe BPD from 36 weeks PMA and onwards, will possibly lead to superior growth of normal lung tissue (assessed indirectly by body weight) at 6 months corrected age, compared to a…
Rehabilitation on skates after ACL reconstruction is non inferior to current common practice.