148 resultaten
We hypothesize that depletion of carnitine occurs during infusion of oxaliplatin, due to increased renal loss. This secondary carnitine deficiency may contribute to the development of CIPN.
We hypothesise that the diet over time has become healthier and more sustainable. Our current study was set up to (1) identify the differences in food consumption and nutritional quality over the course of 20 years in the Netherlands using the…
It is hypothesised that compared to waiting list control condition, participants in the intervention improve their diet and physical activity on the short (6 months after baseline) and long-term (12 months after baseline; when the participant…
What is the influence of protective gear on the performance of basic life support (BLS) by KNRM lifeboat crewmembers during a manikin simulation training
The aim of the project is to gain insight into the effects of centralisation of polytrauma care on the quality of care. We also want to investigate the effect on the quality and quantity of regular trauma care by shifting polytrauma care from…
Patients with obesity face many health issues such as obstructive sleep apnea (OSA). Prevalence of OSA may be as high as 70% in high-risk populations such as morbidly obese patients undergoing bariatric surgery. Although bariatric surgery itself has…
We hypothesize that MTX and LEF combination therapy is superior to MTX monotherapy in patients with psoriatic arthritis
The dutch language version of the PRHWE and the Quick DASH questionnaire are valid to use in patients with hand and wrist complaints
The hypothesis is that testosterone supplementation improves functional mobility, quality of life, body composition, cognitive function, aortic stiffness and cardiovascular risk factors, and bone mineral density compared to placebo.
The absolute bioavailability of oral imatinib (Glivec®) at steady state can be calculated using LC-MS/MS after concomitant administration of a single 100 µg microdose of stable isotope labeled imatinib (imatinib-d8).
Impairment of immune-complex-induced neutrophil activation caused by PDE4 inhibition, making it a potential target for the treatment of pemphigoid diseases.
Primary hypothesis is that MRDTI will demonstrate acceptable sensitivity and specificity for the diagnosis of acute SVT and the differentiation between acute and chronic SVT.
Post-operative rehabilitation consisting of physiotherapy and solution focused therapy will reduce fatigue, improve quality of life and inrease muscle mass in surgically treated HPB patients.
The percentage of receptors responsible for sensibility in the breast (and nipple) differ from the percentage of receptors in the abdominal skin.
Leflunomide is able to reduce the relapses, the glucocorticoid use and the adverse events associated with glucocorticoid s use in PMR patients.
To determine immunogenicity of NIP vaccines in preterm infants when vaccinated according to the current Dutch NIP schedule and with rotavirus vaccine following the RIVAR study. To unravel the mechanism of immature host responses and interaction with…
We test the effect of 1) a verbal suggestion providing a strong under prediction of the pain intensity of upcoming heat stimuli as compared to 2) a verbal suggestion providing a correct prediction of the intensity and 3) a verbal suggestion…
Determining the overall diagnostic performances of WBC scintigraphy, FDG-PET/CT and MRI in trauma patients with suspected fracture-related infections and establish the most accurate imaging strategy for diagnosing (or excluding) fracture related…
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…