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We hypothesize that treating patients with intestinal permeability improving probiotics (in addition to usual treatment; antipsychotic / mood stabilizing treatment) will cause a decrease in psychiatric symptoms (measured with the Brief Psychiatric…
We hypothesize that transient inflammation/infection-associated deep venous thrombosis has a similar recurrence risk as 'classic' provoked deep venous thrombosis.
Allogeneic stem cell transplantation (allo-SCT) is still the treatment of choice for many patients suffering from hematological malignancies, which can only occasionally be cured with conventional chemotherapy. Allo-SCT still associates with a high…
Atherosclerosis is characterized by a persistent inflammation of the arterial wall. Monocyte-derived macrophages are the most abundant immune cells in atherosclerotic plaques. It has recently been shown that not only immune cells of the adaptive…
Oral deuterated water dosing can be used in septic ICU patients to study long-term diurnal muscle protein synthesis rates
We hypothesize that standardized training for endoscopist comprising endoscopic diagnosis followed by a therapeutic plan and high-quality endoscopic resection performance will reduce the number of recurrence after resection of large non-pedunculated…
Pre-hospital triage in patients with low risk of NSTE-ACS will reveal a large saving in health care resources in favor of the pre-hospital rule strategy with additional GP management. At 12 months the strategy will corroborate with a very low event…
In the proposed study we will investigate the effect
Structured cultural sensitive pre-Ramadan education helps people with diabetes who choose to participate in Ramadan fasting to experience a safer Ramadan period. Pre-Ramadan education reduces the risk of acute complications such as hypoglycemia. The…
The objective is to investigate whether application of a stepwise work-up strategy in primary care patients with uncontrolled hypertension results in better blood pressure control in a cost-effective manner.
We hypothesize that intramuscular gluteal corticosteroid injection is non-inferior to intra-articular corticosteroid injection in reducing knee pain in patients with knee osteoarthritis.
The Eleveld propofol PKPD model allows administration of propofol by use of target controlled infusion (TCI) in a broad population (children-adults-elderly-lean-obese).
The study goal is to add the TSR to current routine pathology diagnosis next to the TNM classification.
The effectiveness of the E-health self-management treatment on different domains will be examined. Primarily, it is hypothesized that the treatment results in a lower level of psychological distress, and thereby might facilitate life style changes…
The acceptance and commitment therapy will lead to a greater reduction of depressive and anxiety symptoms in compared to a psycho-education intervention. The acceptance and commitment therapy will lead to less the additional costs and additional…
Treatment with tofacitinib or infliximab show similar changes in lipid and lipoprotein levels in patients with ulcerative colitis
The literature indicates that a minimal endoxifen concentration of 16 nmol/L is needed to produce a therapeutic effect. This implies that the endoxifen levels in individual patients must stay above this threshold throughout the entire treatment…
The cumulative live birth rate after IVF/ICSI is expected to be 8% higher after blastocyst stage embryo transfers (day 5 compared to cleavage stage embryo transfers (day 3). Furthermore, the time to pregnancy will be shorter and less expensive IVF/…