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We hypothesize that cooling reduces endotoxemia induced inflammation and does not cause immunosuppression.
Cast treatment is not inferior to surgical open reduction and internal fixation in terms of patient related outcome measurements.
1. testing the feasibility of the use of an hybrid construction of a CardioMEMS PA sensor and HeartMate III LVAD therapy (with permission of the company Abbott). 2. Hemodynamic guidance improves patient outcome and HF hospitalizations by early…
What are the experiences of members of a citizen's initiative which focuses on a dementia friendly community? And which promoting and inhibiting factors can be found? To become answering outcomes for the research question there will be semi…
Due to the lack of information about DON absorption and excretion, the aims of this study are the description of the DON and metabolites excretions patterns and know the absorption and excretion rates of it. Moreover, the results can be useful to…
Peanut allergy is a common disease, may be lifelong and may be severe. Like other allergic diseases, the prevalence of peanut allergy has increased during the last few decades. Food allergy develops as a consequence of a failure in oral tolerance,…
A relationship can be identified between HbA1c levels and self-management and quality of life. It appears better self-management skills result in a larger improvement of HbA1c levels, and the other way around, getting control over HbA1c levels is a…
The plasma concentrations of inflammatory mediators of AP subjects are similar to those of non-AP controls and elimination of the endodontic infection does not result in changes of the systemic inflammation. Finally ) to investigate the microbiome…
We hypothesize that the ingestion of an additional amount of dietary protein (2 x 15g per day) will increase muscle strength and physical performance in physically active elderly (≥ 65 yrs). Moreover, we hypothesize that the ingestion of additional…
• To evaluate the safety and tolerability of four different single oral doses of LII-291 in healthy subjects. • To characterize the plasma pharmacokinetics (PK) of LTI-291 following single oral dosing in healthy subjects. • To evaluate the…
Infant formulae with higher levels of milk fat result in improved fatty acids absorption as compared to standard formula.
Acid-reducing drugs, such as PPIs, may profoundly decrease solubility and, as a result, (negatively) affect the bioavailability of afatinib. Since a PPI is often used concomitantly during afatinib therapy, this DDI confronts physicians, patients,…
A disease control of 60% is expected and will be clinically relevant with a lower reference bound of 45%.
The aim of this large multicentre prospective cohort study is to compare rib fixation with nonoperative treatment of a flail chest and multiple rib fractures by evaluating treatment effects in ‘real-world’ patients treated in different level 1…
a) What are the effects of the AddictionBeater on alcohol-related approach bias and implicit associations? Participants completing the AddictionBeater and the non-gamified real CBM training would show a greater reduction in alcohol-related approach…
We expect to find little to no uptake of curcumin in the central circulation.
By using an e-Health application to prepare their first consultation with an orthopaedic surgeon, we hypothesize that patients with hip and/or knee osteoarthritis are more informed, ask more specific questions, can take a more active role during the…
To evaluate the anti-inflammatory effects of 3 months statin therapy on vessel wall inflammation by means of FDG PET/CT in patients with CKD.
- How effective are the Acts of Kindness exercises with and without reflection compared to an active control condition and wait-list condition on mental well-being, flourishing, positive relations, gratitude, positive and negative emotions, optimism…