203 resultaten
The study aims to assess the efficacy (in terms of growth response over the years of treatment, including final height) and safety of a treatment regimen consisting of: 1. Authentic biosynthetic growth hormone (GH) in a dosage of 4 IU/m2/day between…
An unsupervised proprioceptive balance board training programme that is applied after the usual care of individual athletes who have sustained an acute sports-related lateral ankle ligament injury is effective for the prevention of ankle sprain…
Locoregional anesthesia does not work as well in patients with the Ehlers-Danlos syndrome as in people who do not have this syndrome.
A self-management programme guided by doctors and a specialist asthma nurse through information and communication technology will improve asthma related quality of life in a cost-effective way.
Systematic screening for type 2 diabetes in high-risk obese subjects, identified from the general population, can significantly reduce the diabetes-related cardiovascular morbidity and mortality by at least 25% compared with not offering a screening…
Implantation of aspheric IOL's results in higher visual performance than spheric IOL's.
Strategies involving shorter and milder ovarian stimulation protocols and single embryo transfer may allow for more IVF cycles in the same period of time, resulting in similar term live birth rate per treatment period despite a minor reduction in…
Assuming that the effects on Parkinson's disease symptoms and dyskinesias, and the rates of procedure-related and device-related complications are almost equal, then continuous bilateral GPi DBS may produce greater functional improvement than…
Combination therapy of steroids plus MTX induces remission faster and will therefor reduce steroid toxicity and disease damage.
Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…
It is hypothised that a pain consult at the specialized pain clinic in combination with Patient Education Program is more effective in reducing average pain intensity compared to a pain consult alone. A pain consult at the specialized pain clinic is…
We will investigate the relationship between S(+)-ketamine plasmaconcentrations and its analgesic effect to estimates the onset/offset times of ketamine and potency parameters for various analgesia tests. This will allow the safer administration of…
To determine the influence of oral medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel and their respective metabolites in cancer patients.
Psychological factors (such as depression, anxiety and life-events) play a role in the onset and course of CRPS1.
The intervention will primarily effect the level of patient control with regard to glycemia, lipid levels and blood pressure. We will expect a substantial decline in the occurrence and severity of complications and mortality and an improved quality…
We hypothesize that the use of Carbon Dioxide (CO2) reduces the incidence of (air) microembolism during aortic arch surgery, and that it also positively influences the gross neurologic and/or the neurocognitive outcome of this kind of surgery.
To determine whether a regular and protocolised intervention at a heart failure (HF) clinic by a combination of a clinician and a cardiovascular nurse, both trained in HF, reduces hospitalisation for worsening HF and/or all cause mortality and…
Inhalation of Delta9-THC will stimulate dopamine release in striatum and its sub-regions.
Patients with Familial Hypobetalipoproteinemia (FHBL) could have increased hepatic glucose production because of hepatic steatosis. Additionally, peripheral insulin sensitivity could be enhanced since these patients have lower concentrations of…
Fluoxetine has in animals and cell cultures neuroprotective properties. We test whether fluoxetine is able to reduce progression in patients with multiple sclerosis.