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It is often advised to cool the upper eyelids immediately after an upper eyelid blepharoplasty and frequently in the first 24 hours in order to reduce pain and minimize edema and bruising of the upper eyelids. However, it has never been…
Women who remained undelivered after an episode of threatened preterm are at increased risk for preterm labor, half of these women will eventually deliver prematurely. No treatment is currently available for these women. This study will investigate…
In order to validate the implementation and efficacy of a novel combination of a reward-learning and stress-processing paradigms, we conduct a computerized behavioural pilot study using healthy volunteers. In the reward-learning paradigm, the main…
DE-MRI is feasible to assess lesion size, transmurality and completeness of PVI. The study will be performed to determine if and how DE-MRI can be used in a larger subsequent multicentre trial (MERCI-AF study).
We hypothesise that the endoscopic transluminal 'step-up' approach, compared to the surgical 'step-up'approach, reduces mortality, major morbidity and costs in patients with (suspected or confirmed) infected necrotising…
Re-administration of gefitinib in EGFR-mutated NSCLC patients will increase DCR.
Maintaining a minimum threshold concentration is relevant for observing optimal benefit with pazopanib. Hurwitz et al demonstrated the interindividual variance in exposure, showing that flat-fixed dosing of 800 mg daily (the currently registered…
Renal artery denervation (RDN) on top of pulmonary vein isolation (PVI) will improve the success of ablative therapy for patients who have paroxysmal and/or persistent atrial fibrillation, with out of range hypertension (systolic >140 mmHg or…
The Hospital Elder Life Program (HELP) has proven (cost)effectiveness in the reduction of delirium incidence in the USA. The primary aim of this study is quantification of the (cost)-effectiveness of HELP in the Dutch Health care system.
To compare the occurrence of significant mask leak when using a nasal mask versus a facemask in preterm infants needing positive pressure ventilation.
Protein Supplement, used for extremely-low-birth-weight (ELBW) infants (< 1000 g) in addition to human milk and/or preterm formula in daily practice, is well tolerated and safe.
We expect that there will be a difference in energy intake after 2 weeks of supplementation of a bar with 10g added fibre out of chirory root pulp (CRP) compared to 2 weeks of supplementation of a control bar. We hypothesize that the energy intake…
By combining Yttrium-90 radioembolization and Radiofrequency Ablation for treatment of patients with colorectal liver metastases, we might be able to target the remnant tumour cells in the rim of the ablation zone and improve the disease free…
To evaluate the incidence, risk factors and perinatal morbidity and mortality due to CA after TTTS treated with fetoscopic laser surgery
The nVision pVLE system may be able to generate real-time, high-resolution mucosal maps of a large surface area of the esophagus, which may aid the endoscopist during surveillance endoscopy in real-time detection of suspicious lesions in patients…
We assume equal improvement of physical function in both groups and reduced costs with conservative treatment.
Patients who have received CRT will have more symptom reduction anda better quality of life after TAU than patients who have not received CRT. Furthermore we hypothesise that CRT will be cost-effective.
To evaluate the targeting performance (including pharmacokinetics/-dynamics) of the human radiolabeled monoclonal-antibody cytokine fusion protein 124I-F8IL10 in 5 patients with rheumatoid arthritis, in a single dose study.
Postoperative pain, further blood loss, onset of delirium and wound discharge are unfavorable factors that can prolong hospital time, delay mobilization and necessitate transfusion. Cryotherapy and pneumatic compression are suggested to minimize…