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Oral bisphosphonate supplementation or the MMR vaccine can be used as immune potentiators when simultaneously administered with BCG, to further amplify the BCG-induced trained immunity response and maximize potential protective effects against COVID…
In T2DM patients with DKD, an acute oral sodium load results in less renal sodium excretion than in healthy individuals and non-DKD T2DM, which can be restored by administration of a GLP-1 receptor agonist.
Based on Faber ea. 2006, we expect that the effectiveness of ‘In Balans’ can be replicated and extended in a group of community-dwelling pre-frail and non-frail older adults with an increased risk of falls, with a significant reduction of the number…
The key objective of this study is to investigate whether modulation of cortical excitability by AEDs (such as levetiracetam), can be reliably measured using TMS-EMG and TMS-EMG in patients with epilepsy. Thereby, this study will assess whether TMS-…
It is hypothesized that beta-alanine supplementation in patients with COPD following a non-linear periodized exercise (NLPE) training program (as part of pulmonary rehabilitation; PR) will increase muscle carnosine levels, which in turn will result…
We hypothesize that the exposure to inulin will strengthen the resilience of the oral ecosystem such that 1) it will be able to withstand experimental gingivitis challenge by maintaining a more health-associated microbiome during this challenge and…
In the first of two substudies, we test the hypothesis that in healthy individuals without ELS, hydrocortisone will be effective in enhancing stress adaptation and extinction learning in an experimental model of exposure therapy, while it is not in…
The main objective is to evaluate the efficacy and safety of phenytoin cream in patients with neuropathic pain due to CIAP
We expect an incidence of delirium in our control group of 30%. This is based on literature documenting incidence of delirium in neurosurgical patients in a northern European population of 29-33%. The expected effect cannot be based on previous…
1. We hypothesize that post exercise whey protein ingestion will increase myofibrillar protein synthesis rates to a greater extent than collagen protein supplementation. 2. We hypothesize that post exercise collagen protein ingestion will increase…
Our hypothesis is that treatment with imatinib results in a reduction of the time to liberation from ventilation and supplemental oxygen and alive in Covid19.
combining a standard DIEP-flap breast reconstruction (BR) with an inguinal lymph node transplant will lead to an improvement of the BCR
It is hypothesized that this mobile intervention will effectively reduce alcohol consumption and binge-drinking frequency.
1. Chronic treatment of 24 weeks with 50 μg roflumilast, compared to placebo, will improve episodic memory in MCI patients 2. Chronic treatment of 24 weeks with 100 μg roflumilast, compared to placebo, will improve episodic memory in MCI patients.
This study hypothesizes that doxapram will protect preterm infants from both invasive ventilation (and related lung disease) and apnea of prematurity related hypoxia (and related impaired brain development).
We assume that single treatment with an anti-IgE monoclonal antibody can inhibit the degree of mast cell activation in atherosclerotic plaque
Investigate the safety and tolerability, and to characterize the pharmacokinetics (PK) of RGH-338 in healthy subjects
Primary objective: - To evaluate the safety and tolerability of NT-0167 in healthy volunteers Secondary: - To evaluate the pharmacokinetic (PK) profile of NT-0167 in healthy volunteers after the administration of single ascending (SAD) and multiple…
Our hypothesis is that critical ill COVID-19 patients suffer more from their own immune response against the virus, than from the viral infection itself. Alkaline phosphatase (RESCAP®) has proven to reduce SIRS reactions by neutralizing the…