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Investigate the acute effect of beetroot juice (BRJ) and high nitrate vegetables (HNV) vs. nitrate depleted beetroot juice (placebo (PL)) on exercise tolerance and vascular function in participants with diagnosed peripheral arterial disease.
Biperiden deteriorate the cognition that biperiden will be used for a challenge model.
To determine the safety and tolerability and to assess the PK and performance of VB5-845D-800CW in healthy volunteers and patients
RTX 1*1000 mg compared to a placebo controlled group leads to a higher proportion of patients in glucocorticoid remission at week 21 in newly diagnosed PMR patients fulfilling the Chuang-criteria
• To evaluate the safety and tolerability of three oral dose levels of LTI-291 following 28 days of LTI-291 treatment in patients with Parkinson’s Disease with GBA-PD. • To characterize the plasma and CSF pharmacokinetics (PK) of LTI-291 following…
Perioperative music has a significant beneficial effect on postoperative pain, which can even be observed when music is played solely during general anaesthesia since auditory sensory information is processed by the brain under deep sedation.…
We hypothesize that TRH effectively antagonize opioid-induced respiratory depression
Crohn’s disease (CD) is a chronic inflammatory bowel disorder (IBD) with a major impact on quality of life. Mucosal healing is an important treatment outcome to prevent long term complications of the disease. Regulatory M2 type macrophages play a…
Ghrelin administration in comatose patients after cardiac arrest is safe, causes no serious adverse events relatable to ghrelin use and it improves functional recovery in these patients.
It is hypothesized that this personally tailored physical activity program (I’M FINE intervention) will be more effective in improving physical fitness and enhance daily activity in individuals with slowly progressive neuromuscular diseases (NMD)…
What is the influence of protective gear on the performance of basic life support (BLS) by KNRM lifeboat crewmembers during a manikin simulation training
Respiratory Syncytial Virus (RSV) is still the leading cause of hospitalization of children under 5 years of age. Currently, there is no effective treatment licensed for an ongoing RSV infection. Therefore, Intravacc develops a live-attenuated…
We hypothesize that UDCA on top of ezetimibe leads to an increased cholesterol excretion via the feces by stimulating ABCG5/8 and preventing absorption of cholesterol due to blocking NPC1L1 and therefore promoting elimination of cholesterol from the…
1. An early screening at 1y of corrected age will identify preterm children with an increased risk of developing visual processing dysfunctions 2. Early visual rehabilitation from 1y of corrected age will benefit the visual and neurocognitive…
Effectiveness of Moving Stories, a game-based school program aimed at depression literacy and stigma
Our first hypothesis is that adolescents who’ve participated in the Moving Stories program will have better mental health literacy and fewer stigmas regarding depression than adolescents who have not participated, both at posttest and at three- and…
We expect that treatment with azelastine/fluticasone propionate will decrease exercise tolerance limitation and will improve quality of life.
Compared to placebo treatment with low dose amitriptyline or mirtazapine during 16 weeks will improve subjective insomnia in insomnia disorder patients in general practice.
The primary objective of this pilot trial is to explore in patients with rheumatoid arthritis (RA) the difference between an intervention and a control group in change from baseline (T0) to at the end of a 4-week bright light therapy (T1) in the…
We hypothesize that endurance athletes receiving protein supplementation report a lower delayed onset muscle soreness score and lower muscle damage biomarker concentrations post-exercise compared to athletes receiving placebo supplementation.
Spinocerebellar ataxia type 3 (SCA3) is the most common subtype among the autosomal dominant cerebellar ataxias, a group of debilitating, progressive conditions for which currently no disease-specific treatment ¨C i.e. aimed at the underlying…