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We hypothesize that liraglutide treatment, initiated before cardiac surgery, is effective in lowering the number of patients needing perioperative insulin adjustments and reducing the total amount of insulin needed in the perioperative period when…
Faecal transplantation from a healthy donor can restore the dysbiosis present in adolescents with refractory IBS, thereby inducing improvement of the IBS complaints.
Our primary hypothesis is that treatment with haloperidol will result in more days alive without delirium or coma during the study period of 14 days. Secondary outcomes are related to delirium and include: mortality, cognitive and functional…
The hypothesis is that receiving additional counselling will lead to greater improvements in behaviour change compared to no additional counselling.
We hypothesise that in the Subacromial Pain Syndrome (SAPS), a differentiation between primary peripheral (i.e. (peri)articular) and secondary pain due to altered processing of pain, i.e. central pain sensitisation, is needed. We further hypothesise…
Tranexamic acid reduces the necessity for surgery and increases quality of life.
A study to validate the results from two RCTs that SCS is indeed capable of treating otherwise refractory diabetic neuropathic pain. In addition, we will evaluate the effects of burst stimulation settings in this patient group.
Common colds have a significant impact on individuals, health care and economy. Functional food ingredients can reduce incidence, duration and severity of common respiratory tract infections in healthy elderly and adults. We hypothesize that test…
Pelvic floor muscle spasms resulting in chronic pelvic pain may occur as a primary event or secondary to a physical, psychological or pathological factor. First-line treatment consists of pelvic floor physiotherapy. When first-line treatment fails,…
The hypothesis is that repeated remote ischaemic postconditioning (by improving vascular, immune and anti-inflammatory pathways) will minimize infarct size and, subsequently, will improve clinical outcome in stroke patients.
Daily protein supplementation during long-term endurance exercise training augments the physiological adaptations to endurance exercise training.
We expect to detect testosterone effects on response to exposure in terms of subjective anxiety and self reported social anxiety symptoms. Additionally we expect testosterone effects on implicit avoidance tendencies. Lastly, Personality traits,…
To confirm that twelve weeks of add-on treatment with bumetanide will improve daily life functioning and reduce behavioral symptoms related to hyperexcitability in children and adolescents with autism spectrum disorder and/or epilepsy.
Acutely hospitalized older patients frequently suffer from inadequate sleep. Insufficient sleep can lead to patient distress and delayed recovery from acute illness or a surgical procedure. Currently, no evidence-based treatments exist for sleeping…
single denosumab injection has a beneficial effect on shortening time in contact cast and foot form preservation in DM subjects with an acute charcot foot
We hypothesize that the epigenetic changes that are related to childhood trauma provide a treatment target for succesful treatment with SAMe of persistent depression in bipolar disorder
The goal of the current study is to examine whether a neutral scent can be conditioned to a stress management training, by examining whether administration of the scent alone can evoke conditioned effects on psychological and physiological stress…
We hypothesize that telephone aftercare for patients of 70 years and older within 24 hours after discharge to a home setting from the ED will lead to a reduction in hospital admission, in avoidable, unanticipated hospital admissions and ED visits…
The study products will result in different stool consistency compared to reference product