871 resultaten
The purpose of the activity and heart rate monitor is to measure and track movement (acceleration) and heartbeat, and derive a number of health-related parameters, which can serve as basis for behavioral change programs leading to e.g. a healthier,…
We hypothesize that the CPA Talking-with-children-intervention will have a beneficial effect on the mental health and quality of life of maltreated children. We expect that children who participate in the CPA investigation (CPA Talking-with-…
We hypothesize that it is possible to culture circulating tumor cells obtained by leukapheresis into organoids.
It is expected that the urinary and serum level of intestinal fatty acid binding protein (I-FABP) and the urinary level of Claudin-3 have prognostic relevance for early identification of patients at risk for intestinal ischemia-related morbidity or…
Tumor-positive lymph nodes in patients with early EAC can be accurately detected through a sentinel node procedure.
Frequently people experience nausea and vomiting following surgery. There are several pharmacologic interventions possible; there is no rational evidence-based approach available. In this study the current therapy regaring PONV and its efficacy in…
We hypothesize that podocyturia is an early marker of ongoing renal damage during angiogenesis inhibition.
Quantification of mast cell density in human volunteers will inform future interventional studies that impact mast cell proliferation and/or turnover
Education on guidelines, combined with quality targets within the accreditation procedure improves quality of antibiotic prescribing
Treatment with Ivacaftor can lead to a therapeutic level of restoration of the CFTR protein channel activity in patients with a class III, S1251N gating mutation. This level of restoration is comparable to a combination of the natural food…
Muscle hypoxia, either chronic or intermittent (exercise-induced), is responsible for the altered muscle oxidative phenotype in chronic obstructive pulmonary disease and chronic heart failure through modulation of the regulatory molecules PGC-1/…
The purpose of the study is to evaluate the outcomes and midterm follow-up in the mini-gastric bypass in terms of weight loss, resolution of co-morbidities and the impact of different BP-limb lengths.
By using a surgical safety checklist, the incidence of postoperative complications will decrease.
The Victoria modules are thought to have a positive effect on acknowlegdement for adversities and risk awareness. This can be used to take acceptable risks in rehabilitation process. This will then lead to more societal participation and less…
We want to study the effect of feedback to the clinician concerning the motivation of the patient to see if this feedback leads to a better motivation, compliance and treatment result because the clinician is more aware of the motivation (or the…
Obinutuzumab can provide clinical benefit in patients with rituximab-refractory follicular lymphoma
An upfront RBCT aiming at low-normal Hb levels will ameliorate anemia-caused tumor hypoxia-related resistance to chemotherapy before the start of chemotherapy and may decrease secondary anemia-induced endogenous release of cytokines like VEGF,…
Previous randomised trials have shown the efficacy of etanercept in RA patients. In this study we will evaluate the respons of etanercept in anti-TNF naive patients compared to patients who have failed other anti-TNF. We will look for clinical…
The EEG profile in responders to methylphenidate will be differ from the EEG profile in non-responders to methylphenidate (i.e. higher total power, increased theta/beta ratio and theta/alpha ratio).
It is hypothesized that the use of a biological mesh will improve primary perineal wound healing and prevent secondary perineal hernia formation compared to primary closure of the perineum.