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Repetitive ePIPAC-OX as a palliative monotherapy is a feasible, safe, tolerable, and potentially effective treatment for isolated unresectable colorectal peritioneal metastases, with low and predictable costs and a low systemic uptake of oxaliplatin…
Objectives are: 1) To determine the feasibility of an OA educational self-management course, by assessing the appreciation of health care providers and participants, participation and barriers and facilitators to participation. 2) To determine…
Providing vascular surgical patients and vascular surgeons with decision support tools will improve the level of shared decision-making during consultation, increase disease-specific knowledge and quality of life and decrease decisional conflict.
To identify (both primary and acquired) resistance mechanisms to chemo-immunotherapy (obtained by less invasive procedures (NGS on ctDNA in blood & urine, exhaled breath or microbioma in stools alone or in combination)) and provide new…
The absolute bioavailability of oral imatinib (Glivec®) at steady state can be calculated using LC-MS/MS after concomitant administration of a single 100 µg microdose of stable isotope labeled imatinib (imatinib-d8).
The aims of this study are twofold: 1. Examine the effectiveness of the web-based CBT self-help intervention for MS-patients with depressive symptoms; 2. Compare characteristics of symptoms of depression and anxiety, quality of life and perceived…
The gastric balloons are expected to remain in the stomach for approximately four weeks, after which they burst and are fecally excreted. It is further hypothesised that intragastric balloons can provide a surrogate stomach fill, inducing an…
Use of exercise instructions by means of a tablet and monitoring by means of a necklace-worn motion sensor is beneficial for adherence in home-based exercise programs for older adults.
The goals of treatment in Crohn’s disease have evolved in recent years from symptom control to healing of mucosal lesions, usually visualized by endoscopy. Potent therapeutic agents, such as anti-TNF agents, have made restoration of mucosal…
The dramatherapeutic Self-concept Module (DZM) will lead to improvement of self-esteem during and after participation in the Dramatherapeutic Self-image module in relation to the baseline, which has been set during psycho-education and /or waiting…
Partners participating in the HmT-online course will show improvement on outcome measures post-treatment and at follow-up compared with pre-treatment scores.
We hypothesize that atopiform dermatitis is a separate entity with specific characteristics, which needs recognition in order to be diagnosed and treated appropriately.
Early oral intake after esophagectomy is feasible and safe.
Approximately 30-40% of patients with pancreatic cancer present with locally advanced pancreatic cancer. Patients with locally advanced pancreatic cancer cannot be surgically resected but at the same time have no clinically detectable distant…
By using FRAM, healthcare professionals will gain more insight into the variability of the healthcare processes, which leads to improved compliance with the selected safety indicators.
We postulate that exhaled breath sampling by an electronic nose can distinguish and adequately identify smell-prints from: 1. Atopic patients without airway obstruction 2. Non-atopic patients without airway obstruction 3. Atopic patients with…
In this pilot cluster randomized control trial, primary care practices will be randomized either into the professional-guided PCFS group (in which patients will be seen by the practice nurse during their regular scheduled consultation follow up of…
We hypothesize that stereotactic radiotherapy for the treatment of the cardiac arrhythmia ventricular tachycardia is effective and safe in therapy refractory patients
We would further elucidate the presence of hypersensitivity in EoE and its relation to the esophageal mucosal integrity