23 resultaten
We expect brain activity and brain reactivity to change as satiation progresses. ROI are : Brainstem (dorsal vagal complex (DVC), nucleus tractus solitarius (NTS), parabrachial nucleus (PBN)), Hypothalamus, Insula, overlying operculum, secondary:…
Targeted Next Generation Sequencing (NGS) can distinguish benign pancreatic diseases, such as pancreatitis, from pancreatic malignancies during the diagnostic proces of patients with an uncertain diagnosis and treatment plan.
Type 2 diabetes is cause by progressive beta-cell dysfunction against a background of obesity and insulin resistance in susceptible individuals. Peroxisome proliferator-activated receptor (PPAR) gamma-mediated mechanisms are involved in the…
Adolescence represents a crucial stage in the maturation of executive functioning (e.g. working memory and inhibition) and mental health (i.e. behavioral and emotional functioning, and self-concept), which both are important predictors of academic…
Comparison of two new techniques for detection of small bowel pathology: MR enteroclysis and videocapsule enteroscopy with double-balloon enteroscopy with respect to diagnostic yield, accuracy of findings, and patient preference.
1. Straatwijzer 2.0 leads to improvements in the knowledge of youths with mild intellectual disabilities (MID) and their parents about the characteristics of their MID, and about the frequently occurring psychiatric disorders ADHD, autism, conduct…
The present study is a feasibility study. In this study we will test the feasibility of the procedures used, the compliance to the interventions, and the usefulness of intermediate outcome measures in a specific high risk group. If the results of…
Maintenance thalidomide delays the time to progression with 50% in patients who do not progress after > 3 cycles of pemetrexed containing chemotherapy.
Salt restriction is an effective strategy to attenuate or prevent VEGF inhibitor-induced toxicity, primarily the rise in blood pressure.
Addition of alternative tests (TEG/ROTEM® and/or TGA) which reflect the whole hemostatic status of a patient might help recognizing the level of thrombin formation and fibrinolysis and improve care in ECMO patients and potentially reduce the risk of…
We hypothesize that a conversation aid and information brochure for patients, and a communication training for physicians improves satisfaction and quality of the discussion about potential treatment restrictions at the internal medicine outpatient…
We hypothesize that anxiety symptoms worsen after follow-up imaging compared to patients baseline anxiety levels.
1. Using a wobble cushion and tangle will lead to improved performance on a math test, reading comprehension test and on a sustained attention test for children with more problems with sensory information processing (both low and high threshold) in…
The overall aim of this study is to implement bariatric surgery including the multidisciplinary care pathway around the procedure for unsuccessfully treated adolescents with severe obesity in the Netherlands. Therefore, feasibility, efficacy and…
Multiple sclerosis (MS) is a brain disease, in which myelin sheaths in the brain and spinal cord are damaged. If repair of myelin damage is incomplete, nerve terminals will be irreversibly destroyed, leading to neurological symptoms. Ineffective…
We expect that there will be a restrictive condition in the first place. After a longer period there may be an obstructive condition, due to the original infection. We expect that the leucocyte count of the pleural fluid, the number of loculations…
To demonstrate superiority over time in treatment of pain of best medical practice with adjunctive SCS Therapy compared to best medical practice without SCS Therapy in patients with chronic diabetic neuropathic pain as measured by VAS score.
Enhanced endoscopic imaging, including high-definition white light endoscopy and virtual chromoendoscopy, alongside targeted biopsies provides an accurate and reproducible assessment of chronic atrophic gastritis disease extent and staging, when…
The use of ECLS can lead to systemic inflammatory response. It is likely that ECLS affects red blood cell and platelet function after its initiation, the time course of these changes and their clinical relevance is yet unclear.