31 resultaten
Primary hypotheses The primary hypothesis of the present study is that included patients who receive continuous or intermittent oxygen and bilevel positive pressure ventilation during fixed work rate treadmill exercise tests have shorter recovery…
To determine the role of 5-HT2 and 5-HT1A receptors in learning and memory. It is expected that: 1. An acute dose of MDMA will produce impairments on laboratory measures of learning and memory; 2. MDMA-induced memory impairment will be reversed…
Fatigue affects central nervous system function and, in the setting of the medical profession, could influence specialist performance, patient care and safety. ln contrast to other industries, for example the aviation industry, there are no "…
We hypothesize that TIPS placement has an significant effect on drug metabolism and bile acid metabolism.
The main hyothesis of the experiments is that a dual action antidepressant (duloxetine) modulates functions in specific brain areas involved in the processing bias of emotional stimuli in the context of neutral versus depressed mood.
We expect that patients with a IDH mutation demonstrate an increase in 2-HG on MR spectroscopy. We also expect a positive correlation between in vivo 2-HG on MR spectroscopy and ex vivo concentration in tissue.
A relationship exists between a pharmacologic effect of ENX-201 and the plasma concentration
Whether the bioavailability of ciprofloxacin oral suspension and tablets are equivalent and can therefore be used interchangeably.
The main objective of the human dietary intervention study is to investigate the beneficial health effects of food products containing various combinations of an equivalent of 400 grams vegetables and fruits in healthy volunteers. This will be…
For cochlear implanted (CI) patients speech recognition in noise still remains one of the most challenging tasks. One way to improve performance in noise is to benefit from binaural hearing (hearing with two ears). For individuals with residual…
A nursing nutrition intervention improves protein and energy intake and performance based on hand grip strength compared to usual care.
The primary objective of this study is to validate MRI as a functional measuring device for directly monitoring gastric emptying in vivo
Primary Objective: Investigate the effect of modafinil (200 mg) and caffeine (300 mg) on vigilance in low, medium and high caffeine consumers during the circadian trough in order to determine: - To what extend vigilance during the circadian trough…
We hypothesize that the circulatory and cardiac effects of TEA will be most pronounced during circumstances of increased sympathicotonus, which will be induced by an exercise test on a bicycle.
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Primary objective: To determine the safety of once daily inhalation of the recommended daily dose of tobramycin with the Akita® and the PARI-LC® Plus nebulizer in patients with CF. Systemic absorption can be used as surrogate parameter for safety.…
The primary objective of this study is to investigate if a specifically designed VR-game is able to activate the pathophysiological substrate associated with OCD in OCD patients, as opposed to healthy controls. This will be investigated by…
We hypothesize that a single night of short sleep duration (4 hours), compared to normal sleep duration (8 hours) reduces metabolic flexibility, increases insulin resistance and thereby reduces HPA-reactivity. Furthermore, we hypothesize that a…