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1. The addition of moderate positive end-expiratory pressure (PEEP, 7.5 cmH2O) to high inspiratory fractions of oxygen can either improve oxygenation or reduce respiratory rate, or both, in patients with severe Covid-19 pneumonia 2. The application…
Primary hypothesis is whether patients with a PTSD the distraction of a positive emotional valence will be more effective in decreasing the vividness and emotionality of a traumatic memory compared to distraction with a neutral task or exposure only…
Since probenecid is a potent multi UGT inhibitor, endoxifen concentrations may be significantly (and clinically relevantly) increased when administered concomitantly with probenecid.
Flexible RPD's have a higher impact on OHRQoL compared to acrylic RPD's.
We hypothesize that especially the reward centres of the brain respond much stronger to processed food in BED, whereas much smaller differences are expected after consuming unprocessed food.
In the first of two substudies, we test the hypothesis that in healthy individuals without ELS, hydrocortisone will be effective in enhancing stress adaptation and extinction learning in an experimental model of exposure therapy, while it is not in…
Using inhaled volatile anaesthetic agents as the primary sedative during mechanically ventilation in patients with COVID-19-associated ARDS improves gas exchange and ventilatory support requirements
2C-B generates distinct acute and subacute effects from Psilocybin and placebo
Our hypothesis is that growth hormone threatment in adults with Prader-Willi Syndrome will improve their metabolic and cardiovascuar health, thereby resulting in a reduced mortality.
The post-prandial rise in total amino acid, proline and glycine concentration following a single bout of resistance exercise will be the highest in the 20 gr whey combined with 10 gr collagen compared to all other test drinks
exercise improves social functioning, quality of life and decreases symptom severity
Adding specific components designed to target three risk factors for child maltreatment (parental stress, parental anger, and post-traumatic stress symptoms) to an evidence-based home visiting program alleviates these specific risk factors.
In T2DM patients with DKD, an acute oral sodium load results in less renal sodium excretion than in healthy individuals and non-DKD T2DM, which can be restored by administration of a GLP-1 receptor agonist.
Cognitive remediation focused on executive functioning for patients with bipolar disorder improves executive functioning on (1) personal goals in daily life, and (2) general well-being. Exploratory hypotheses: - Cognitive remediation focused on…
We hypothesize that added neurometabolite measurements can contribute to the interpretation of the ketamine phMRI response.
Home blood pressure measurement and 24 hour ambulatory blood pressure monitoring will be in good agreement with each other
• clonazepam administration has acute beneficial effects compared to placebo on neurocognitive tests. • multiple-doses clonazepam has beneficial effects compared to placebo on behaviour and cognitive function in ARID1B patients as measured by the…
The hypothesis of this study is that implementation of an evidence-based management algorithm to standardize care will improve the level of care, lower the complication rate and improve the quality of life for patients with chronic pancreatitis.
It is expected that patients prefer the AFO with the best efficacy, and that the preference is reliable at the moment of AFO fitting.
Tamoxifen is metabolized in two steps, by CYP3A4 and CYP2D6, into endoxifen. Thereafter it is glucuronidated to its inactive excretable form through several UGT enzymes (UGT2B7, UGT1A4, UGT1A10 and UGT1A8) into endoxifen-glucuronide. CBD could also…