151 resultaten
Cine-MRI is able to detect adhesions in the pouch of Douglas in endometriosis patients by visualizing the presence or absence of the sliding viscera sign.
LRRK2 kinase inhibitors represent a new class of therapeutics with potential to address the underlying biology of Parkinson’s disease. LRRK2 activity is linked to a central mechanisms of Parkinson’s disease pathology through its role in lysosomal…
Sodium phenylbutyrate administration in patients with T2D would improve whole body insulin sensitivity.
It is expected that differences in energy density of the study products will modulate the protein digestion profile of dairy proteins in elderly
The hypothesis is that the Manometric brace is superior to conventional plaster braces in terms of patient satisfaction, compliance and patient preference. For pain and hand function, no superior outcomes are expected for the Manometric brace…
In the first of two substudies, we test the hypothesis that in healthy individuals without ELS, hydrocortisone will be effective in enhancing stress adaptation and extinction learning in an experimental model of exposure therapy, while it is not in…
We want to determine the influence and safety of probenecid on sorafenib pharmacokinetics. By inhibiting the OAT6 transporter there might be a faborable effect on Hand-foot syndrome
The study hypothesis is that FFCiH will maintain or improve functional status and physical activity in hospitalized stroke and geriatric patients compared to usual care.
The composition of a meal might influence the effect of breaking up prolonged sitting on cognition
By providing patients reliable information and daily checklists via an app, we aim to give the patient a tool to be involved in the management of the catheter use. In this way, inappropriate use should be better signaled and discouraged, and the…
The addition of arabinose to a sucrose load leads to a decreased or delayed entry of glucose, derived from the ingested sucrose, into the circulation and a decreased glycemic response and insulinemic response when compared to sucrose only.
We hypothesize that cardiac output rather than blood pressure is essential for adequate cerebral perfusion during and after cerebral revascularization.
The post-prandial rise in total amino acid, proline and glycine concentration following a single bout of resistance exercise will be the highest in the 20 gr whey combined with 10 gr collagen compared to all other test drinks
- Intradialytic protein ingestion increases plasma total amino acid concentrations throughout hemodialysis compared to placebo. - Intradialytic exercise increases amino acid loss into the dialysate in fasted patients and decreases amino acid loss…
The intended research aims to evaluate whether a better suppression of adrenal androgens, so a better hormonal setting, can be achieved by changing the time of the highest dose in the morning or in the evening.
The hypothesis formulation for the primary outcome parameter is: - H0: The effect of using product A is unequal to the effect of using product B with respect to serum P AUC0-360 [mmol/L*min] in subjects with elevated gastric pH. - H1: The effect of…
Het doel van dit onderzoek is om twee verschillende antiarritmica soorten (sotalol en combinatie van flecainide/verapamil) en katheter ablatie te vergelijken in de effectiviteit om PVC/VT burden te reduceren bij patienten met symptomatische *…
Het effect van orale sham feeding en het intragastrisch aanbieden van kinine (een bittere smaakstof) op voedselinname onderzoeken.
Bepalen of polystyreensulfonaat een effect heeft op de blootstelling van amitriptyline wanneer het gelijktijdig wordt ingenomen, in vergelijking met amitriptyline dat alleen wordt ingenomen bij gezonde vrijwilligers, uitgedrukt in Cmax en AUC0-8u.
Double-blinded periode:Het primaire doel van de studie is:• Het onderzoeken van de veiligheid en verdraagbaarheid van 28 dagen SAR443060 oraal gedoseerd in patiënten met ALS.De secundaire doelen zijn:• Het karakteriseren van de farmacokinetiek (PK)…