32 resultaten
Tumour cell disruption by radiation generates a surplus of neo-antigens that enhances the effect of immunotherapy in solid malignancies as well as malignant lymphomas. The hypothesis is that the combination of immune checkpoint inhibitors and…
Golimumab 100 mg every 1,5 month has similar trough levels to golimumab 50 mg every month; golimumab 100 mg every 2 months has a similar AUC to golimumab 50 mg every month.
Main hypothesis The BENEFIT intervention will significantly increase the number of CVD patients that can maintain the healthy lifestyle behavior most relevant to them for at least one year, compared to care-as-usual. Secondary hypothesis The BENEFIT…
Interaction between oral dexamethasone and aprepitant is different than the interaction between iv dexamethasone and aprepitant.
1. DKD patients are salt-sensitive due to a decreased sodium buffering capacity (damaged ESL). As a consequence a high sodium diet will lead to water retention, resulting in increased ECF, body weight and blood pressure. 2. CKD patients are salt-…
We hypothesize that the MMP could be cost-efficient for a part of the patients, but that for some patients a more simple prosthesis would be more cost-efficient. Therefore, we do not expect big differences in cost-effectiveness between the MMP and…
Better glucose control during the closed loop system compared to standard open loop therapy
Hypothesis 1. The slopes of improvement are significantly stronger during ST than during control conditions (baseline, ST-preparation, communication training, follow-up). Hypothesis 2. The slopes of improvement in the sequence ST - Communication…
Treatment with chloroquine or hydroxychloroquine of adult patients admitted with moderate to severe COVID-19, a NEWS-2 score ≤5, reduces the proportion of patients who show progression of their disease defined as a NEWS-2 score ≥ 7(22), admission to…
The flavonoid-drug interaction could potentially lead to higher nintedanib absorption by the gastro-intestinal tract. This would cause higher systemic bioavailability and lower local gastro-intestinal drug concentrations. Furthermore, inter-patient…
ICS can be safely withdrawn in T2-low asthma patients with obesity in secondary care (i.e. without loss of asthma control).
Smart energy meter data used in a monitoring system to alert users when out-of-the-ordinary activity is detected, may improve health-related quality of life and perceived safety of community-dwelling older persons and their informal care providers.
• Overall, the patient-tailored PROfeel lifestyle advice will be more effective in reducing patients’ fatigue severity than the generic dietary advice. • Overall, the patient-tailored PROfeel lifestyle advice will have a more positive effect on…
We expect higher bioavailability of seaweed types containing more inorganic iodine, compared to seaweed types containing more or organic iodine.
Polystyrene sulfonate shows an in-vitro binding interaction with amitriptyline, causing 70-80% binding of amitriptyline to polystyrene sulfonate. The hypothesis is that polystyrene sulfonate binds to amitriptyline when taken simoultaneously in…
The intended research aims to evaluate whether a better suppression of adrenal androgens, so a better hormonal setting, can be achieved by changing the time of the highest dose in the morning or in the evening.
We hypothesize that both remote ischemic conditioning and exercise conditioning activate the release of circulating blood factors. We expect that the repeated application shows higher levels op these circulating blood factors
In is hypothesized that the glycemic response to standardized snacks differs within subjects between different times of the day
We hypothesize that the use of KomPas at the start and during the SET will be associated with increased functional walking distance, maximal walking distance and the quality of life of patients with Intermittent Claudication. Moreover, we…
Effective SCS affects brain activity that is related with chronic pain