14488 resultaten
The purpose of this study is: 1. To identify clinical and biological predictors for the development of IRIS in HIV infected patients and; 2. To obtain insight into the pathogenesis of this syndrome; 3. To describe the epidemiological pattern of IRIS…
1a. Changes in outcome measures of anxiety can be partly explained by changes in self-reported thougths; 1b. Changes in outcome measures of anxiety can be partly explained by changes in selective attention and by changes in fear relevant cognitive…
Patients who are in 1st CR after autologous transplantation, may be randomized between no further treatment (arm A) and maintenance chemotherapy (arm B). The hypothesis to be tested is that maintenance therapy will prolong disease free survival,…
1, the effect of SLT diminishes in time; how fast does IOP get below target IOP after SLT? 2, is a repeat SLT effective to get/keep IOP under target IOP? 3, is there a racial difference in effect of SLT?
Intrathecal methylprednisolone reduce the features of central sensitization in patients with complex regional pain syndrome type 1 having symptoms longer than 6 months and shorter than 6 years.
Assessment of feasibility of neoadjuvant chemotherapy consisting of docetaxel, cisplatin and capecitabine in resectable localized gastric cancer (stage Ib-IVa) and the introduction of the D1extra-lymphadenectomy as the standardized surgical…
Research questions: 1. What are the effects of the addition of preventive CT to AD compared to AD alone in remitted patients with recurrent MDD with a follow-up of 15 months-24 months on: A. Time related proportion of depression recurrence; B. The…
A more gradual training program for novice runners, will result in a reduction of running related injuries in novice runners.
An increase in subjective memory performance will result in increased quality of life and social participation.
The actual ERAS statement regarding intra- and postoperative analgesia recommends to not use thoracic epidural catheters in laparoscopic surgery anymore as a gold standard. This cohort study will investigate an alternative possibility of pain…
1. There are differences of thermoregulatory behavior and thermo-physiology between healthy lean and obese subjects. 2. Healthy lean and obese individuals can be classified based on individual thermal preference, which is a result of distinct…
The main objective of the present study is to evaluate (cost)effectiveness of Dementia Care Mapping (DCM)intervention in nursing home dementia care by performing a large RCT study.
MMR vaccine administered intramuscularly induces the same adverse effects and immunogenicity as subcutaneously.
We hypothesize that the Ketogenic diet will be cost-effective compared to usual care.
Stabilisation of preterm infants performing physioloigcal based cord clamping using the Concord is at least as effective as stabilisation according to the standard approach using the standard resusciation table.
To assess the outcomes of endoscopic hernia repair (TEP) after implantation of a lightweight mesh (Ultrapro) versus a heavyweight mesh (Prolene). The hypothesis is that an endoscopic hernia repair with implantation of a lightweight mesh results in…
To compare a ventilation strategy that uses conservative targets (PaO2 55-80 mmHg (7.3-10.7 kPa)) with one that uses conventional oxygenation targets (PaO2 110-150 mmHg (14.7-20 kPa)) for arterial oxygenation. Primary endpoint is all-cause mortality…
Operative treatment with additional concentrated bone marrow cells results in better fifth metatarsal stress fracture healing than operative treatment alone. We furthermore hypothesize that composition of bone marrow cells also contributes to…
1. Gatekeeper training is effective in enhancing relevant skills 2. Gatekeeper training will diminish rates of (attempted) suicides at regional level 3. The intervention is cost-effective relative to routine medical care
1. Daily home monitoring of exhaled nitric oxide (FENO) in patients with severe asthma facilitate tapering of oral corticosteroids to the lowest possible dose, leading to a reduction of total corticosteroid consumption; 2. This can be achieved…