1411 resultaten
NEDERLANDS Samenvattend onderzoekt dit project de klinische effectiviteit en bruikbaarheid van een nieuwe interventie voor het verbeteren van ziekte-inzicht die wordt ingezet vanaf de start van de (poli)klinische cognitieve revalidatie van patiënten…
De effectiviteit van tocilizumab in vergelijking met prednison bij patienten met reumatoide artritis
In rheumatoid arthritis (RA) patients with insufficient response to disease modifying anti-rheumatic drugs (DMARDs) it is unknown whether addition of tocilizumab (TCZ) to conventional synthetic (cs) DMARDs has superior efficacy compared to addition…
Primary aim: 1. To investigate whether differences exist in the mitochondrial energy generating capacity of skeletal muscle of statin users with SAMS compared to statin users without SAMS and controls (non-statin users). Secondary aims: 2A. To…
Treatment of a subcapital metacarpal fifth fracture with a compression bandage gives the same functional outcome a treatment with paris plaster
Hypothesis 1: Participants in both conditions (experimental and placebo) will show a reduction in gamble problem severity immediately post-intervention and at 3-and 6-month follow-ups. However, participants in the experimental condition will show a…
In line with a previous pilot study we hypothesize that 3MDR will significantly decrease PTSD symptom severity in treatment resistant veterans with chronic PTSD in comparison with treatment as usual.
Discontinuation of long term use of antipsychotics for behavioral symptoms in patients with mental retardation does not lead to deterioration in mental functioning.
This study is a phase I trial, testing the safety and toxicity of allogeneic NK cell infusions with an escalating dose of ex vivo expanded NK cells following immunosuppressive conditioning therapy in elderly patients with AML.
To develop a dosing nomogram of irinotecan in patients homozygous polymorphic for UGT1A1*28 and/or UGT1A1*93 in order to reduce the incidence of severe irinotecan-associated toxicity, defined as febrile neutropenia in the first 2 cycles (amendment…
- Smokers are implicitly biased with regard to the pros/cons of smoking (more attention and/or approach tendencies with regard to the pros) - These biases can be retrained using implicit pictorial trainings based on the Visual Probe Task and the…
Mindfulness training as well as medication will reduce symptoms of attention, hyperactivity and impulsivity, not only directly after training but also at follow-up.
A combination therapy (MDT and TESIs) is effective and cost-effective compared to usual care among herniated nucleus pulpos patients with an indication for a lumbar herniated disc surgery
A strategy aimed to switch from INR-guided VKA therapy to a NOAC-based treatment strategy is superior to continuation of INR-guided VKA therapy with regard to the occurrence of major or clinically relevant non-major bleeding complications in frail…
This study aims to underpin the delivery of longstanding exercise therapy in the subgroup of patients with axSpA and complex disability. There are 3 research questions to be addressed: 1. Is longstanding, optimized active exercise therapy more…
N/A
The RAINBOW study: Rheumatoid Arthritis ImplemeNtation of Biological dose Optimization in real World
We hypothesize that a multifaceted implementation strategy can stimulate the use of tight control and bDMARD dose optimization in clinical practice, measured by decreased bDMARD use and non-inferiority on disease activity at 18 months.
1. Personalised tools and technologies help to stimulate an increased compliance to a healthy lifestyle in people with overweight and/or obesity and who are cardio-metabolically compromised. Increased compliance may (eventually) lead to a more…
Saphenus blok reduceerd opname duur na epifysiodese van de knie - een triple blind superiority trial
We hypothesize that a single shot saphenous nerve block in combination with general anesthesia would be superior to general anesthesia alone regarding opiod consumption. pain scores. recovery and length of stay in adolecent patients undergoing…
It is possible to detect altered DNA from endometrial and ovarian cancer cells in the Pap-smear by analysing a set of predetermined genes
We hypothesize that the ingestion of quark will increase post-prandial muscle protein synthesis at rest in both young and older men. In addition, we hypothesize that exercise will augment the post-prandial muscle protein synthetic response to quark…