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Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
The aim of this phase I study is to assess the extent of intestinal absorption of rivaroxaban and dabigatran etexilate in adult patients with short bowel syndrome requiring long-term TPN.
It is hypothesized that respiratory depression from the opioid oxycodone will increase with concomitant administration of alcohol. Furthermore it is hypothesized that the increase in respiratory depression is not only dependent on the dosage of…
The primary goal of this trial is to demonstrate that a physical activity program, which consists of an exercise program and follow-up care under supervision of a specialized physiotherapist, can prevent the frequently observed decline in global…
It is hypothesized that placement of a single implant with tissue grafting will lead to less mid-facial soft tissue recession.
We hypothesize that: 1. Elderly in each of the intervention neighbourhoods will have more favorable outcomes: A. Elderly living in neighbourhoods were the both physical and social environmental changes are made will have the most favorable outcomes…
We hypothesize that massage with aromatherapy or massage with carrier oil enhances relaxation whereas no intervention does not. We hypothesize that massage with essential oils is more effective than massage without essential oils.
This will be the first randomized controlled trial of an integrated intervention in patients with BD and comorbid BPF. Given the overlapping phenomenology, the research will contribute to better understanding of similarities and differences between…
The primary endpoint of this study is the change in perfused boundary region (PBR) during cardiopulmonary bypass (CPB). We assume that a heparin coated extracorporeal circuit, due to its comparable biochemical structure, is more biocompatible with…
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There is no reliable biological marker for the diagnosis of Acute Mountain Sickness (AMS), so AMS is presently assessed with questionnaires: the Lake Louise self-report score (LLSRS) and the abbreviated Environmental Symptoms Questionnaire (ESQc).…
The treatment-effects of Narrative Exposure Rationale: In mental health services older adults represent a growing, but under-investigated population. However, trauma-related psychopathology for older adults represent robust, but often hidden…
Severe fatigue is a common complaint after completion of breast cancer treatment with curative intent. To extend treatment options for postcancer fatigue, the efficacy of an internet therapy with minimal therapist support is examined in the current…
To investigate whether either chlorhexidine-alcohol or iodine-alcohol based skin antiseptics is more protective against surgical site infections.
To evaluate if topical corticosteroid plus emollient cream is efficacious as topical corticosteroid applied twice daily in mild to moderate plaque psoriasis
The blastocyst formation rate of frozen-thawed donated human pre-implantation embryos cultured in a microfluidic platform is higher than in a standard culture dish.
Wider implementation of CBT for CFS is hampered by the fact that the treatment is time consuming for both patient and therapist. Therefore it is important to develop treatment programmes that require less treatment capacity. In the present study we…
With the program Alcohol Alert we will reduce binge drinking of 16 to 18 year old dutch adolescents, through focusing on motivational factors (eg. attitude, self-efficacy), peer factors (eg. peer pressure, modeling, social norm) and parental factors…
We aim to test the hypotheses that offering additional online adaptive coaching to a web-based self-management program will be more effective than a web-based self-management program without coaching in terms of self-management behaviour without…
A lower amount of cold soluble galactomannans (0.33g per 100ml) is as effective as 0.45g/100ml of hot soluble galactomannans in reducing the number of visible and invisible refluxes.